Genetic variation in the endocannabinoid system and response to Cognitive Behavior Therapy for child anxiety disorders

Kathryn J. Lester; Jonathan Coleman; Susanna Roberts; Robert Keers; Gerome Breen; Susan Bögels; Cathy Creswell; Jennifer L. Hudson; Anna Mckinnon; Maaike Nauta; Ronald M. Rapee; Silvia Schneider; Wendy K. Silverman; Mikael Thastum; Polly Waite; Gro Janne H Wergeland; Thalia C. Eley

doi:10.1002/ajmg.b.32467

Genetic variation in the endocannabinoid system and response to Cognitive Behavior Therapy for child anxiety disorders

Kathryn J. Lester^*, Jonathan Coleman, Susanna Roberts, Robert Keers, Gerome Breen, Susan Bögels, Cathy Creswell, Jennifer L. Hudson, Anna Mckinnon, Maaike Nauta, Ronald M. Rapee, Silvia Schneider, Wendy K. Silverman, Mikael Thastum, Polly Waite, Gro Janne H Wergeland, Thalia C. Eley

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

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Abstract

Extinction learning is an important mechanism in the successful psychological treatment of anxiety. Individual differences in response and relapse following Cognitive Behavior Therapy may in part be explained by variability in the ease with which fears are extinguished or the vulnerability of these fears to re-emerge. Given the role of the endocannabinoid system in fear extinction, this study investigates whether genetic variation in the endocannabinoid system explains individual differences in response to CBT. Children (N=1,309) with a primary anxiety disorder diagnosis were recruited. We investigated the relationship between variation in the CNR1, CNR2, and FAAH genes and change in primary anxiety disorder severity between pre- and post-treatment and during the follow-up period in the full sample and a subset with fear-based anxiety disorder diagnoses. Change in symptom severity during active treatment was nominally associated (P

Original language	English
Journal	American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
Early online date	27 Jun 2016
DOIs	https://doi.org/10.1002/ajmg.b.32467
Publication status	E-pub ahead of print - 27 Jun 2016

Keywords

Anxiety
Children
Cognitive Behavior Therapy
Endocannabinoids
Fear extinction

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ajmg.b.32467Licence: CC BY

Genetic variation in the endocannabinoid_LESTER_Accepted 25May2016_GOLD VoRFinal published version, 146 KBLicence: CC BY

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Lester, K. J., Coleman, J., Roberts, S., Keers, R., Breen, G., Bögels, S., Creswell, C., Hudson, J. L., Mckinnon, A., Nauta, M., Rapee, R. M., Schneider, S., Silverman, W. K., Thastum, M., Waite, P., Wergeland, G. J. H., & Eley, T. C. (2016). Genetic variation in the endocannabinoid system and response to Cognitive Behavior Therapy for child anxiety disorders. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. Advance online publication. https://doi.org/10.1002/ajmg.b.32467

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abstract = "Extinction learning is an important mechanism in the successful psychological treatment of anxiety. Individual differences in response and relapse following Cognitive Behavior Therapy may in part be explained by variability in the ease with which fears are extinguished or the vulnerability of these fears to re-emerge. Given the role of the endocannabinoid system in fear extinction, this study investigates whether genetic variation in the endocannabinoid system explains individual differences in response to CBT. Children (N=1,309) with a primary anxiety disorder diagnosis were recruited. We investigated the relationship between variation in the CNR1, CNR2, and FAAH genes and change in primary anxiety disorder severity between pre- and post-treatment and during the follow-up period in the full sample and a subset with fear-based anxiety disorder diagnoses. Change in symptom severity during active treatment was nominally associated (P",

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Lester, KJ , Coleman, J , Roberts, S , Keers, R , Breen, G, Bögels, S, Creswell, C, Hudson, JL, Mckinnon, A, Nauta, M, Rapee, RM, Schneider, S, Silverman, WK, Thastum, M, Waite, P, Wergeland, GJH & Eley, TC 2016, 'Genetic variation in the endocannabinoid system and response to Cognitive Behavior Therapy for child anxiety disorders', American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. https://doi.org/10.1002/ajmg.b.32467

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AU - Bögels, Susan

AU - Creswell, Cathy

AU - Hudson, Jennifer L.

AU - Mckinnon, Anna

AU - Nauta, Maaike

AU - Rapee, Ronald M.

AU - Schneider, Silvia

AU - Silverman, Wendy K.

AU - Thastum, Mikael

AU - Waite, Polly

AU - Wergeland, Gro Janne H

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Genetic variation in the endocannabinoid system and response to Cognitive Behavior Therapy for child anxiety disorders

Abstract

Keywords

UN SDGs

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