Genetic variation in the endocannabinoid system and response to Cognitive Behavior Therapy for child anxiety disorders

Kathryn J. Lester*, Jonathan Coleman, Susanna Roberts, Robert Keers, Gerome Breen, Susan Bögels, Cathy Creswell, Jennifer L. Hudson, Anna Mckinnon, Maaike Nauta, Ronald M. Rapee, Silvia Schneider, Wendy K. Silverman, Mikael Thastum, Polly Waite, Gro Janne H Wergeland, Thalia C. Eley

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)
160 Downloads (Pure)

Abstract

Extinction learning is an important mechanism in the successful psychological treatment of anxiety. Individual differences in response and relapse following Cognitive Behavior Therapy may in part be explained by variability in the ease with which fears are extinguished or the vulnerability of these fears to re-emerge. Given the role of the endocannabinoid system in fear extinction, this study investigates whether genetic variation in the endocannabinoid system explains individual differences in response to CBT. Children (N=1,309) with a primary anxiety disorder diagnosis were recruited. We investigated the relationship between variation in the CNR1, CNR2, and FAAH genes and change in primary anxiety disorder severity between pre- and post-treatment and during the follow-up period in the full sample and a subset with fear-based anxiety disorder diagnoses. Change in symptom severity during active treatment was nominally associated (P

Original languageEnglish
JournalAmerican Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
Early online date27 Jun 2016
DOIs
Publication statusE-pub ahead of print - 27 Jun 2016

Keywords

  • Anxiety
  • Children
  • Cognitive Behavior Therapy
  • Endocannabinoids
  • Fear extinction

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