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Genetic variation is associated with RTN4R expression and working memory processing in healthy humans

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Genetic variation is associated with RTN4R expression and working memory processing in healthy humans. / Lo Bianco, Luciana; Attrotto, Maria Teresa; Torretta, Silvia; Masellis, Rita; Rampino, Antonio; D'Ambrosio, Enrico; Giorgio, Annabella Di; Ferranti, Laura; Fazio, Leonardo; Gelao, Barbara; Blasi, Giuseppe; Bertolino, Alessandro.

In: Brain Research Bulletin, 26.07.2017.

Research output: Contribution to journalArticle

Harvard

Lo Bianco, L, Attrotto, MT, Torretta, S, Masellis, R, Rampino, A, D'Ambrosio, E, Giorgio, AD, Ferranti, L, Fazio, L, Gelao, B, Blasi, G & Bertolino, A 2017, 'Genetic variation is associated with RTN4R expression and working memory processing in healthy humans', Brain Research Bulletin. https://doi.org/10.1016/j.brainresbull.2017.07.015

APA

Lo Bianco, L., Attrotto, M. T., Torretta, S., Masellis, R., Rampino, A., D'Ambrosio, E., Giorgio, A. D., Ferranti, L., Fazio, L., Gelao, B., Blasi, G., & Bertolino, A. (2017). Genetic variation is associated with RTN4R expression and working memory processing in healthy humans. Brain Research Bulletin. https://doi.org/10.1016/j.brainresbull.2017.07.015

Vancouver

Lo Bianco L, Attrotto MT, Torretta S, Masellis R, Rampino A, D'Ambrosio E et al. Genetic variation is associated with RTN4R expression and working memory processing in healthy humans. Brain Research Bulletin. 2017 Jul 26. https://doi.org/10.1016/j.brainresbull.2017.07.015

Author

Lo Bianco, Luciana ; Attrotto, Maria Teresa ; Torretta, Silvia ; Masellis, Rita ; Rampino, Antonio ; D'Ambrosio, Enrico ; Giorgio, Annabella Di ; Ferranti, Laura ; Fazio, Leonardo ; Gelao, Barbara ; Blasi, Giuseppe ; Bertolino, Alessandro. / Genetic variation is associated with RTN4R expression and working memory processing in healthy humans. In: Brain Research Bulletin. 2017.

Bibtex Download

@article{491043f9147c4889bfea97a03d6bfe34,
title = "Genetic variation is associated with RTN4R expression and working memory processing in healthy humans",
abstract = "The Nogo receptor (NgR) is implicated in neurodevelopmental processes and it participates in inhibiting axonal growth. Consistent with its high levels of expression in the prefrontal cortex, animal studies indicate that NgR is relevant for prefrontal-related cognitive processing. Given that genetic variation may alter mechanisms of gene expression impacting molecular and systems-level phenotypes, we investigated the association of genetic variation with the expression of the NgR coding gene (RTN4R), as well as with prefrontal correlates at progressively greater biological distance from gene effects. First, we studied the association of single nucleotide polymorphisms (SNPs) with RTN4R mRNA expression in postmortem prefrontal cortex of humans without psychiatric illnesses. Then, we probed in peripheral blood mononuclear cells (PBMCs) the association that we found in prefrontal tissue. Thus, we investigated whether functional genetic variation affecting RTN4R expression is also associated with prefrontal activity during working memory. We found that rs696884 (A/G) predicted these phenotypes. Specifically, the AA genotype was associated with lower RTN4R mRNA expression levels in the prefrontal cortex and PBMCs and inefficient prefrontal activity during working memory compared to the GG genotype. These results suggest that genetic variation associated with RTN4R mRNA expression influences prefrontal physiology in healthy individuals. Furthermore, they highlight the need for further investigations of the role of NgR in the pathophysiology of brain disorders associated with prefrontal dysfunction.",
keywords = "rs696884, Nogo Receptor, mRNA expression, prefrontal activity, working memory",
author = "{Lo Bianco}, Luciana and Attrotto, {Maria Teresa} and Silvia Torretta and Rita Masellis and Antonio Rampino and Enrico D'Ambrosio and Giorgio, {Annabella Di} and Laura Ferranti and Leonardo Fazio and Barbara Gelao and Giuseppe Blasi and Alessandro Bertolino",
year = "2017",
month = jul,
day = "26",
doi = "10.1016/j.brainresbull.2017.07.015",
language = "English",
journal = "Brain Research Bulletin",
issn = "0361-9230",
publisher = "Elsevier B.V.",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Genetic variation is associated with RTN4R expression and working memory processing in healthy humans

AU - Lo Bianco, Luciana

AU - Attrotto, Maria Teresa

AU - Torretta, Silvia

AU - Masellis, Rita

AU - Rampino, Antonio

AU - D'Ambrosio, Enrico

AU - Giorgio, Annabella Di

AU - Ferranti, Laura

AU - Fazio, Leonardo

AU - Gelao, Barbara

AU - Blasi, Giuseppe

AU - Bertolino, Alessandro

PY - 2017/7/26

Y1 - 2017/7/26

N2 - The Nogo receptor (NgR) is implicated in neurodevelopmental processes and it participates in inhibiting axonal growth. Consistent with its high levels of expression in the prefrontal cortex, animal studies indicate that NgR is relevant for prefrontal-related cognitive processing. Given that genetic variation may alter mechanisms of gene expression impacting molecular and systems-level phenotypes, we investigated the association of genetic variation with the expression of the NgR coding gene (RTN4R), as well as with prefrontal correlates at progressively greater biological distance from gene effects. First, we studied the association of single nucleotide polymorphisms (SNPs) with RTN4R mRNA expression in postmortem prefrontal cortex of humans without psychiatric illnesses. Then, we probed in peripheral blood mononuclear cells (PBMCs) the association that we found in prefrontal tissue. Thus, we investigated whether functional genetic variation affecting RTN4R expression is also associated with prefrontal activity during working memory. We found that rs696884 (A/G) predicted these phenotypes. Specifically, the AA genotype was associated with lower RTN4R mRNA expression levels in the prefrontal cortex and PBMCs and inefficient prefrontal activity during working memory compared to the GG genotype. These results suggest that genetic variation associated with RTN4R mRNA expression influences prefrontal physiology in healthy individuals. Furthermore, they highlight the need for further investigations of the role of NgR in the pathophysiology of brain disorders associated with prefrontal dysfunction.

AB - The Nogo receptor (NgR) is implicated in neurodevelopmental processes and it participates in inhibiting axonal growth. Consistent with its high levels of expression in the prefrontal cortex, animal studies indicate that NgR is relevant for prefrontal-related cognitive processing. Given that genetic variation may alter mechanisms of gene expression impacting molecular and systems-level phenotypes, we investigated the association of genetic variation with the expression of the NgR coding gene (RTN4R), as well as with prefrontal correlates at progressively greater biological distance from gene effects. First, we studied the association of single nucleotide polymorphisms (SNPs) with RTN4R mRNA expression in postmortem prefrontal cortex of humans without psychiatric illnesses. Then, we probed in peripheral blood mononuclear cells (PBMCs) the association that we found in prefrontal tissue. Thus, we investigated whether functional genetic variation affecting RTN4R expression is also associated with prefrontal activity during working memory. We found that rs696884 (A/G) predicted these phenotypes. Specifically, the AA genotype was associated with lower RTN4R mRNA expression levels in the prefrontal cortex and PBMCs and inefficient prefrontal activity during working memory compared to the GG genotype. These results suggest that genetic variation associated with RTN4R mRNA expression influences prefrontal physiology in healthy individuals. Furthermore, they highlight the need for further investigations of the role of NgR in the pathophysiology of brain disorders associated with prefrontal dysfunction.

KW - rs696884

KW - Nogo Receptor

KW - mRNA expression

KW - prefrontal activity

KW - working memory

U2 - 10.1016/j.brainresbull.2017.07.015

DO - 10.1016/j.brainresbull.2017.07.015

M3 - Article

JO - Brain Research Bulletin

JF - Brain Research Bulletin

SN - 0361-9230

ER -

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