Abstract
This chapter reviews the current literature on genetic and epigenetic mechanisms and their potential role in the development and/or maintenance of chronic pain conditions. First, different sources of genetic variation are discussed, as well as the tools available for their study and the most notable findings that have so far emerged in the pain research community. These include identification of human genetic variation in known candidate genes and, more recently, in novel targets identified via genome-wide screening. Secondly, higher level and possibly more stable alterations in gene function are described, such as DNA methylation and histone modifications. Such epigenetic mechanisms are starting to generate research interest, studies indicating that they may be implicated in relevant chronic pain models and may contribute to some differences observed in interindividual risk for painful disorders.
Original language | English |
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Title of host publication | An Introduction to Pain and Nervous System Disorders |
Publisher | WILEY-BLACKWELL |
Pages | 149-167 |
Number of pages | 19 |
ISBN (Electronic) | 9781118455968 |
ISBN (Print) | 9781118455913 |
DOIs | |
Publication status | Published - 5 Mar 2016 |
Keywords
- Chronic pain
- DNA methylation
- Epigenetics
- Genetics
- Genome-wide association study
- Histone modifications
- Linkage analysis
- Single nucleotide polymorphism (SNP)