Genetics and neurobiology of eating disorders

TY - JOUR

T1 - Genetics and neurobiology of eating disorders

AU - Bulik, Cynthia M

AU - Coleman, Jonathan R I

AU - Hardaway, J Andrew

AU - Breithaupt, Lauren

AU - Watson, Hunna J

AU - Bryant, Camron D

AU - Breen, Gerome

N1 - Funding Information: C.M.B. is supported by the National Institute of Mental Health (R01MH120170, R01MH124871, R01MH119084, R01MH118278 and R01MH124871), a Brain and Behavior Research Foundation Distinguished Investigator grant, the Swedish Research Council (Vetenskapsrådet, award no. 538-2013-8864), and the Lundbeck Foundation (grant no. R276-2018-4581). J.R.I.C. and G.B. acknowledge that the paper represents independent research part funded by the National Institute for Health Research (NIHR) Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. J.A.H. is supported by K01DK115902. C.D.B. is supported by U01DA050243 and U01DA055299. L.B. is supported by T32MH112485, a Harvard Medical School Livingston Fellowship and the International OCD Foundation. G.B. is also supported by the UK Medical Research Council (MR/V012878/1, MR/V03605X/1 and MR/R024804/1) and Charlotte’s Helix. Publisher Copyright: © 2022, Springer Nature America, Inc.

PY - 2022/5/6

Y1 - 2022/5/6

N2 - Eating disorders (anorexia nervosa, bulimia nervosa and binge-eating disorder) are a heterogeneous class of complex illnesses marked by weight and appetite dysregulation coupled with distinctive behavioral and psychological features. Our understanding of their genetics and neurobiology is evolving thanks to global cooperation on genome-wide association studies, neuroimaging, and animal models. Until now, however, these approaches have advanced the field in parallel, with inadequate cross-talk. This review covers overlapping advances in these key domains and encourages greater integration of hypotheses and findings to create a more unified science of eating disorders. We highlight ongoing and future work designed to identify implicated biological pathways that will inform staging models based on biology as well as targeted prevention and tailored intervention, and will galvanize interest in the development of pharmacologic agents that target the core biology of the illnesses, for which we currently have few effective pharmacotherapeutics.

AB - Eating disorders (anorexia nervosa, bulimia nervosa and binge-eating disorder) are a heterogeneous class of complex illnesses marked by weight and appetite dysregulation coupled with distinctive behavioral and psychological features. Our understanding of their genetics and neurobiology is evolving thanks to global cooperation on genome-wide association studies, neuroimaging, and animal models. Until now, however, these approaches have advanced the field in parallel, with inadequate cross-talk. This review covers overlapping advances in these key domains and encourages greater integration of hypotheses and findings to create a more unified science of eating disorders. We highlight ongoing and future work designed to identify implicated biological pathways that will inform staging models based on biology as well as targeted prevention and tailored intervention, and will galvanize interest in the development of pharmacologic agents that target the core biology of the illnesses, for which we currently have few effective pharmacotherapeutics.

KW - Animals

KW - Anorexia Nervosa

KW - Binge-Eating Disorder/psychology

KW - Bulimia Nervosa/psychology

KW - Feeding and Eating Disorders/genetics

KW - Genome-Wide Association Study

UR - http://www.scopus.com/inward/record.url?scp=85129723779&partnerID=8YFLogxK

U2 - 10.1038/s41593-022-01071-z

DO - 10.1038/s41593-022-01071-z

M3 - Review article

C2 - 35524137

SN - 1097-6256

VL - 25

SP - 543

EP - 554

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 5

ER -