| Original language | English |
|---|---|
| Title of host publication | eLS |
| ISBN (Electronic) | 9780470015902 |
| DOIs | |
| Publication status | Published - 19 Sept 2013 |
Abstract
Probing the genetic basis of depression not only informs our understanding of the role that genes play in disease, but also further offers the potential to provide invaluable insights into the aetiology, classification and neurobiology of the disorder. Moreover, understanding the genetics of depression may offer a starting point for the development of novel, and potentially more efficacious treatments for patients.
Although a number of genes have been implicated in depression, a genetic variant that is unequivocally associated with an increased risk of the disease is yet to be identified. As genome-wide approaches to analysing genetic variation gain momentum, large-scale collaborations have brought insights into how best to conceptualise depression as an illness. Nonetheless, the identification of specific genetic variants associated with depression still eludes researchers. By building on the knowledge gained from these collaborative datasets, and utilising newer and more sophisticated technologies and methodologies, it is likely that researchers will be able to replicate in depression, the successes of genetic research in other complex disorders.
Although a number of genes have been implicated in depression, a genetic variant that is unequivocally associated with an increased risk of the disease is yet to be identified. As genome-wide approaches to analysing genetic variation gain momentum, large-scale collaborations have brought insights into how best to conceptualise depression as an illness. Nonetheless, the identification of specific genetic variants associated with depression still eludes researchers. By building on the knowledge gained from these collaborative datasets, and utilising newer and more sophisticated technologies and methodologies, it is likely that researchers will be able to replicate in depression, the successes of genetic research in other complex disorders.