Genetics of Depression: Progress at Last

Niamh Mullins; Cathryn M. Lewis

doi:10.1007/s11920-017-0803-9

Genetics of Depression: Progress at Last

Niamh Mullins, Cathryn M. Lewis

Research output: Contribution to journal › Article › peer-review

99 Citations (Scopus)

276 Downloads (Pure)

Abstract

PURPOSE OF REVIEW: We will describe the success of recent genome-wide association studies that identify genetic variants associated with depression and outline the strategies used to reduce heterogeneity and increase sample size.

RECENT FINDINGS: The CONVERGE consortium identified two genetic associations by focusing on a sample of Chinese women with recurrent severe depression. Three other loci have been found in Europeans by combining cohorts with clinical diagnosis and measures of depressive symptoms to increase sample size. 23andMe identified 15 loci associated with depression using self-report of clinical diagnosis in a study of over 300,000 individuals. The first genetic associations with depression have been identified, and this number is now expected to increase linearly with sample size, as seen in other polygenic disorders. These loci provide invaluable insights into the biology of depression and exciting opportunities to develop new biomarkers and therapeutic targets.

Original language	English
Article number	43
Pages (from-to)	1-7
Journal	CURRENT PSYCHIATRY REPORTS
Volume	19
Issue number	8
Early online date	13 Jun 2017
DOIs	https://doi.org/10.1007/s11920-017-0803-9
Publication status	Published - Aug 2017

Keywords

Journal Article
Review

Access to Document

10.1007/s11920-017-0803-9Licence: CC BY

Genetics of Depression_MULLINS Epub 13 June 2017_ GOLD VoR CC BYFinal published version, 1.02 MBLicence: CC BY

Cite this

@article{e1799ad935164299ae3ea7ff6806a0ed,

title = "Genetics of Depression: Progress at Last",

abstract = "PURPOSE OF REVIEW: We will describe the success of recent genome-wide association studies that identify genetic variants associated with depression and outline the strategies used to reduce heterogeneity and increase sample size.RECENT FINDINGS: The CONVERGE consortium identified two genetic associations by focusing on a sample of Chinese women with recurrent severe depression. Three other loci have been found in Europeans by combining cohorts with clinical diagnosis and measures of depressive symptoms to increase sample size. 23andMe identified 15 loci associated with depression using self-report of clinical diagnosis in a study of over 300,000 individuals. The first genetic associations with depression have been identified, and this number is now expected to increase linearly with sample size, as seen in other polygenic disorders. These loci provide invaluable insights into the biology of depression and exciting opportunities to develop new biomarkers and therapeutic targets.",

keywords = "Journal Article, Review",

author = "Niamh Mullins and Lewis, {Cathryn M.}",

year = "2017",

month = aug,

doi = "10.1007/s11920-017-0803-9",

language = "English",

volume = "19",

pages = "1--7",

journal = "CURRENT PSYCHIATRY REPORTS",

issn = "1523-3812",

publisher = "Current Medicine Group",

number = "8",

}

TY - JOUR

T1 - Genetics of Depression

T2 - Progress at Last

AU - Mullins, Niamh

AU - Lewis, Cathryn M.

PY - 2017/8

Y1 - 2017/8

N2 - PURPOSE OF REVIEW: We will describe the success of recent genome-wide association studies that identify genetic variants associated with depression and outline the strategies used to reduce heterogeneity and increase sample size.RECENT FINDINGS: The CONVERGE consortium identified two genetic associations by focusing on a sample of Chinese women with recurrent severe depression. Three other loci have been found in Europeans by combining cohorts with clinical diagnosis and measures of depressive symptoms to increase sample size. 23andMe identified 15 loci associated with depression using self-report of clinical diagnosis in a study of over 300,000 individuals. The first genetic associations with depression have been identified, and this number is now expected to increase linearly with sample size, as seen in other polygenic disorders. These loci provide invaluable insights into the biology of depression and exciting opportunities to develop new biomarkers and therapeutic targets.

AB - PURPOSE OF REVIEW: We will describe the success of recent genome-wide association studies that identify genetic variants associated with depression and outline the strategies used to reduce heterogeneity and increase sample size.RECENT FINDINGS: The CONVERGE consortium identified two genetic associations by focusing on a sample of Chinese women with recurrent severe depression. Three other loci have been found in Europeans by combining cohorts with clinical diagnosis and measures of depressive symptoms to increase sample size. 23andMe identified 15 loci associated with depression using self-report of clinical diagnosis in a study of over 300,000 individuals. The first genetic associations with depression have been identified, and this number is now expected to increase linearly with sample size, as seen in other polygenic disorders. These loci provide invaluable insights into the biology of depression and exciting opportunities to develop new biomarkers and therapeutic targets.

KW - Journal Article

KW - Review

U2 - 10.1007/s11920-017-0803-9

DO - 10.1007/s11920-017-0803-9

M3 - Article

C2 - 28608123

SN - 1523-3812

VL - 19

SP - 1

EP - 7

JO - CURRENT PSYCHIATRY REPORTS

JF - CURRENT PSYCHIATRY REPORTS

IS - 8

M1 - 43

ER -

Genetics of Depression: Progress at Last

Abstract

Keywords

Access to Document

Fingerprint

Cite this