Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)

Andre Franke; Tobias Balschun; Christian Sina; David Ellinghaus; Robert Haesler; Gabriele Mayr; Mario Albrecht; Michael Wittig; Eva Buchert; Susanna Nikolaus; Christian Gieger; H. Erich Wichmann; Jurgita Sventoraityte; Limas Kupcinskas; Clive M. Onnie; Maria Gazouli; Nicholas P. Anagnou; David Strachan; Wendy L. McArdle; Christopher G. Mathew; Paul Rutgeerts; Severine Vermeire; Morten H. Vatn; Michael Krawczak; Philip Rosenstiel; Tom H. Karlsen; Stefan Schreiber

doi:10.1038/ng.553

Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)

Andre Franke, Tobias Balschun, Christian Sina, David Ellinghaus, Robert Haesler, Gabriele Mayr, Mario Albrecht, Michael Wittig, Eva Buchert, Susanna Nikolaus, Christian Gieger, H. Erich Wichmann, Jurgita Sventoraityte, Limas Kupcinskas, Clive M. Onnie, Maria Gazouli, Nicholas P. Anagnou, David Strachan, Wendy L. McArdle, Christopher G. MathewPaul Rutgeerts, Severine Vermeire, Morten H. Vatn, Michael Krawczak, Philip Rosenstiel, Tom H. Karlsen, Stefan Schreiber

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Abstract

We performed a genome-wide association analysis of 1,897,764 SNPs in 1,043 German ulcerative colitis (UC) cases and 1,703 controls. We discovered new associations at chromosome 7q22 (rs7809799) and at chromosome 22q13 in IL17REL (rs5771069) and confirmed these associations in six replication panels (2,539 UC cases and 5,428 controls) from different regions of Europe (overall study sample P-rs7809799 = 8.81 x 10(-11) and P-rs5771069 = 4.21 x 10(-8), respectively).

Original language	English
Pages (from-to)	292 - 294
Number of pages	3
Journal	Nature Genetics
Volume	42
Issue number	4
DOIs	https://doi.org/10.1038/ng.553
Publication status	Published - Apr 2010

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Franke, A., Balschun, T., Sina, C., Ellinghaus, D., Haesler, R., Mayr, G., Albrecht, M., Wittig, M., Buchert, E., Nikolaus, S., Gieger, C., Wichmann, H. E., Sventoraityte, J., Kupcinskas, L., Onnie, C. M., Gazouli, M., Anagnou, N. P., Strachan, D., McArdle, W. L., ... Schreiber, S. (2010). Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). Nature Genetics, 42(4), 292 - 294. https://doi.org/10.1038/ng.553

@article{9c74b72df0f1436ca647c41dc1c2a4fd,

title = "Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)",

abstract = "We performed a genome-wide association analysis of 1,897,764 SNPs in 1,043 German ulcerative colitis (UC) cases and 1,703 controls. We discovered new associations at chromosome 7q22 (rs7809799) and at chromosome 22q13 in IL17REL (rs5771069) and confirmed these associations in six replication panels (2,539 UC cases and 5,428 controls) from different regions of Europe (overall study sample P-rs7809799 = 8.81 x 10(-11) and P-rs5771069 = 4.21 x 10(-8), respectively).",

author = "Andre Franke and Tobias Balschun and Christian Sina and David Ellinghaus and Robert Haesler and Gabriele Mayr and Mario Albrecht and Michael Wittig and Eva Buchert and Susanna Nikolaus and Christian Gieger and Wichmann, {H. Erich} and Jurgita Sventoraityte and Limas Kupcinskas and Onnie, {Clive M.} and Maria Gazouli and Anagnou, {Nicholas P.} and David Strachan and McArdle, {Wendy L.} and Mathew, {Christopher G.} and Paul Rutgeerts and Severine Vermeire and Vatn, {Morten H.} and Michael Krawczak and Philip Rosenstiel and Karlsen, {Tom H.} and Stefan Schreiber",

year = "2010",

month = apr,

doi = "10.1038/ng.553",

language = "English",

volume = "42",

pages = "292 -- 294",

journal = "Nature Genetics",

issn = "1546-1718",

publisher = "Nature Research",

number = "4",

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Franke, A, Balschun, T, Sina, C, Ellinghaus, D, Haesler, R, Mayr, G, Albrecht, M, Wittig, M, Buchert, E, Nikolaus, S, Gieger, C, Wichmann, HE, Sventoraityte, J, Kupcinskas, L, Onnie, CM, Gazouli, M, Anagnou, NP, Strachan, D, McArdle, WL, Mathew, CG, Rutgeerts, P, Vermeire, S, Vatn, MH, Krawczak, M, Rosenstiel, P, Karlsen, TH & Schreiber, S 2010, 'Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)', Nature Genetics, vol. 42, no. 4, pp. 292 - 294. https://doi.org/10.1038/ng.553

TY - JOUR

T1 - Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)

AU - Franke, Andre

AU - Balschun, Tobias

AU - Sina, Christian

AU - Ellinghaus, David

AU - Haesler, Robert

AU - Mayr, Gabriele

AU - Albrecht, Mario

AU - Wittig, Michael

AU - Buchert, Eva

AU - Nikolaus, Susanna

AU - Gieger, Christian

AU - Wichmann, H. Erich

AU - Sventoraityte, Jurgita

AU - Kupcinskas, Limas

AU - Onnie, Clive M.

AU - Gazouli, Maria

AU - Anagnou, Nicholas P.

AU - Strachan, David

AU - McArdle, Wendy L.

AU - Mathew, Christopher G.

AU - Rutgeerts, Paul

AU - Vermeire, Severine

AU - Vatn, Morten H.

AU - Krawczak, Michael

AU - Rosenstiel, Philip

AU - Karlsen, Tom H.

AU - Schreiber, Stefan

PY - 2010/4

Y1 - 2010/4

N2 - We performed a genome-wide association analysis of 1,897,764 SNPs in 1,043 German ulcerative colitis (UC) cases and 1,703 controls. We discovered new associations at chromosome 7q22 (rs7809799) and at chromosome 22q13 in IL17REL (rs5771069) and confirmed these associations in six replication panels (2,539 UC cases and 5,428 controls) from different regions of Europe (overall study sample P-rs7809799 = 8.81 x 10(-11) and P-rs5771069 = 4.21 x 10(-8), respectively).

AB - We performed a genome-wide association analysis of 1,897,764 SNPs in 1,043 German ulcerative colitis (UC) cases and 1,703 controls. We discovered new associations at chromosome 7q22 (rs7809799) and at chromosome 22q13 in IL17REL (rs5771069) and confirmed these associations in six replication panels (2,539 UC cases and 5,428 controls) from different regions of Europe (overall study sample P-rs7809799 = 8.81 x 10(-11) and P-rs5771069 = 4.21 x 10(-8), respectively).

U2 - 10.1038/ng.553

DO - 10.1038/ng.553

M3 - Article

SN - 1546-1718

VL - 42

SP - 292

EP - 294

JO - Nature Genetics

JF - Nature Genetics

IS - 4

ER -

Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)

Abstract

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