Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure

Alessia Visconti; David Duffy; Fan Liu; Gu Zhu; Wenting Wu; Yan Chen; Pirro Hysi; Changqing Zeng; Marianna Sanna; Mark M Iles; Peter A. Kanetsky; Florence Demenais; Merel A Hamer; Andre G. Uitterlinden; M. Arfan Ikram; Tamar E C Nijsten; Nicholas G. Martin; Manfred Kayser; Timothy David Spector; Jiali Han; Veronique Bataille; Mario Falchi

doi:10.1038/s41467-018-04086-y

Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure

Alessia Visconti, David Duffy, Fan Liu, Gu Zhu, Wenting Wu, Yan Chen, Pirro Hysi, Changqing Zeng, Marianna Sanna, Mark M Iles, Peter A. Kanetsky, Florence Demenais, Merel A Hamer, Andre G. Uitterlinden, M. Arfan Ikram, Tamar E C Nijsten, Nicholas G. Martin, Manfred Kayser, Timothy David Spector, Jiali HanVeronique Bataille, Mario Falchi

Twin Research & Genetic Epidemiology

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Abstract

The skin’s tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report a large genome-wide association study of ease of skin tanning in 176,678 subjects of European ancestry. We identify significant association with tanning ability at 20 loci. We confirm previously identified associations at six of these loci, and report 14 novel loci, of which ten have never been associated with pigmentation-related phenotypes. Our results also suggest that variants at the AHR/AGR3 locus, previously associated with cutaneous malignant melanoma the underlying mechanism of which is poorly understood, might act on disease risk through modulation of tanning ability.

Original language	English
Article number	1684
Journal	Nature Communications
DOIs	https://doi.org/10.1038/s41467-018-04086-y
Publication status	Published - 8 May 2018

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Genome-wide association study_VISCONTI_Published8May2018_GOLD VoR (CC BY)Final published version, 696 KBLicence: CC BY

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Visconti, A., Duffy, D., Liu, F., Zhu, G., Wu, W., Chen, Y., Hysi, P., Zeng, C., Sanna, M., Iles, M. M., Kanetsky, P. A., Demenais, F., Hamer, M. A., Uitterlinden, A. G., Ikram, M. A., Nijsten, T. E. C., Martin, N. G., Kayser, M., Spector, T. D., ... Falchi, M. (2018). Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure. Nature Communications, Article 1684. https://doi.org/10.1038/s41467-018-04086-y

@article{a42df10e1e7746b882a067929fdfe60c,

title = "Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure",

abstract = "The skin{\textquoteright}s tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report a large genome-wide association study of ease of skin tanning in 176,678 subjects of European ancestry. We identify significant association with tanning ability at 20 loci. We confirm previously identified associations at six of these loci, and report 14 novel loci, of which ten have never been associated with pigmentation-related phenotypes. Our results also suggest that variants at the AHR/AGR3 locus, previously associated with cutaneous malignant melanoma the underlying mechanism of which is poorly understood, might act on disease risk through modulation of tanning ability.",

author = "Alessia Visconti and David Duffy and Fan Liu and Gu Zhu and Wenting Wu and Yan Chen and Pirro Hysi and Changqing Zeng and Marianna Sanna and Iles, {Mark M} and Kanetsky, {Peter A.} and Florence Demenais and Hamer, {Merel A} and Uitterlinden, {Andre G.} and Ikram, {M. Arfan} and Nijsten, {Tamar E C} and Martin, {Nicholas G.} and Manfred Kayser and Spector, {Timothy David} and Jiali Han and Veronique Bataille and Mario Falchi",

year = "2018",

month = may,

day = "8",

doi = "10.1038/s41467-018-04086-y",

language = "English",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Research",

}

Visconti, A, Duffy, D, Liu, F, Zhu, G, Wu, W, Chen, Y, Hysi, P, Zeng, C, Sanna, M, Iles, MM, Kanetsky, PA, Demenais, F, Hamer, MA, Uitterlinden, AG, Ikram, MA, Nijsten, TEC, Martin, NG, Kayser, M, Spector, TD, Han, J, Bataille, V & Falchi, M 2018, 'Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure', Nature Communications. https://doi.org/10.1038/s41467-018-04086-y

TY - JOUR

T1 - Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure

AU - Visconti, Alessia

AU - Duffy, David

AU - Liu, Fan

AU - Zhu, Gu

AU - Wu, Wenting

AU - Chen, Yan

AU - Hysi, Pirro

AU - Zeng, Changqing

AU - Sanna, Marianna

AU - Iles, Mark M

AU - Kanetsky, Peter A.

AU - Demenais, Florence

AU - Hamer, Merel A

AU - Uitterlinden, Andre G.

AU - Ikram, M. Arfan

AU - Nijsten, Tamar E C

AU - Martin, Nicholas G.

AU - Kayser, Manfred

AU - Spector, Timothy David

AU - Han, Jiali

AU - Bataille, Veronique

AU - Falchi, Mario

PY - 2018/5/8

Y1 - 2018/5/8

N2 - The skin’s tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report a large genome-wide association study of ease of skin tanning in 176,678 subjects of European ancestry. We identify significant association with tanning ability at 20 loci. We confirm previously identified associations at six of these loci, and report 14 novel loci, of which ten have never been associated with pigmentation-related phenotypes. Our results also suggest that variants at the AHR/AGR3 locus, previously associated with cutaneous malignant melanoma the underlying mechanism of which is poorly understood, might act on disease risk through modulation of tanning ability.

AB - The skin’s tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report a large genome-wide association study of ease of skin tanning in 176,678 subjects of European ancestry. We identify significant association with tanning ability at 20 loci. We confirm previously identified associations at six of these loci, and report 14 novel loci, of which ten have never been associated with pigmentation-related phenotypes. Our results also suggest that variants at the AHR/AGR3 locus, previously associated with cutaneous malignant melanoma the underlying mechanism of which is poorly understood, might act on disease risk through modulation of tanning ability.

U2 - 10.1038/s41467-018-04086-y

DO - 10.1038/s41467-018-04086-y

M3 - Article

SN - 2041-1723

JO - Nature Communications

JF - Nature Communications

M1 - 1684

ER -

Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure

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