Genome-wide association study of motor coordination problems in ADHD identifies genes for brain and muscle function

Ellen A. Fliers; Alejandro Arias Vasquez; Geert Poelmans; Nanda Rommelse; Marieke Altink; Cathelijne Buschgens; Philip Asherson; Tobias Banaschewski; Richard Ebstein; Michael Gill; Ana Miranda; Fernando Mulas; Robert D. Oades; Herbert Roeyers; Aribert Rothenberger; Joseph Sergeant; Edmund Sonuga-Barke; Hans-Christoph Steinhausen; Stephen V. Faraone; Jan K. Buitelaar; Barbara Franke

doi:10.3109/15622975.2011.560279

Genome-wide association study of motor coordination problems in ADHD identifies genes for brain and muscle function

Ellen A. Fliers, Alejandro Arias Vasquez, Geert Poelmans, Nanda Rommelse, Marieke Altink, Cathelijne Buschgens, Philip Asherson, Tobias Banaschewski, Richard Ebstein, Michael Gill, Ana Miranda, Fernando Mulas, Robert D. Oades, Herbert Roeyers, Aribert Rothenberger, Joseph Sergeant, Edmund Sonuga-Barke, Hans-Christoph Steinhausen, Stephen V. Faraone, Jan K. BuitelaarBarbara Franke

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Objectives. Motor coordination problems are frequent in children with attention deficit/hyperactivity disorder (ADHD). We performed a genome-wide association study to identify genes contributing to motor coordination problems, hypothesizing that the presence of such problems in children with ADHD may identify a sample of reduced genetic heterogeneity. Methods. Children with ADHD from the International Multicentre ADHD Genetic (IMAGE) study were evaluated with the Parental Account of Children's Symptoms. Genetic association testing was performed in PLINK on 890 probands with genome-wide genotyping data. Bioinformatics enrichment-analysis was performed on highly ranked findings. Further characterization of the findings was conducted in 313 Dutch IMAGE children using the Developmental Coordination Disorder Questionnaire (DCD-Q). Results. Although none of the findings reached genome-wide significance, bioinformatics analysis of the top-ranked findings revealed enrichment of genes for motor neuropathy and amyotrophic lateral sclerosis. Genes involved in neurite outgrowth and muscle function were also enriched. Among the highest ranked genes were MAP2K5, involved in restless legs syndrome, and CHD6, causing motor coordination problems in mice. Further characterization of these findings using DCD-Q subscales found nominal association for 15 SNPs. Conclusions. Our findings provide clues about the aetiology of motor coordination problems, but replication studies in independent samples are necessary.

Original language	English
Pages (from-to)	211 - 222
Number of pages	12
Journal	World Journal of Biological Psychiatry
Volume	13
Issue number	3
DOIs	https://doi.org/10.3109/15622975.2011.560279
Publication status	Published - Mar 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3109/15622975.2011.560279

Cite this

Fliers, E. A., Vasquez, A. A., Poelmans, G., Rommelse, N., Altink, M., Buschgens, C., Asherson, P., Banaschewski, T., Ebstein, R., Gill, M., Miranda, A., Mulas, F., Oades, R. D., Roeyers, H., Rothenberger, A., Sergeant, J., Sonuga-Barke, E., Steinhausen, H.-C., Faraone, S. V., ... Franke, B. (2012). Genome-wide association study of motor coordination problems in ADHD identifies genes for brain and muscle function. World Journal of Biological Psychiatry, 13(3), 211 - 222. https://doi.org/10.3109/15622975.2011.560279

@article{57240affb625414cb0ba1f4cb88e9a73,

title = "Genome-wide association study of motor coordination problems in ADHD identifies genes for brain and muscle function",

abstract = "Objectives. Motor coordination problems are frequent in children with attention deficit/hyperactivity disorder (ADHD). We performed a genome-wide association study to identify genes contributing to motor coordination problems, hypothesizing that the presence of such problems in children with ADHD may identify a sample of reduced genetic heterogeneity. Methods. Children with ADHD from the International Multicentre ADHD Genetic (IMAGE) study were evaluated with the Parental Account of Children's Symptoms. Genetic association testing was performed in PLINK on 890 probands with genome-wide genotyping data. Bioinformatics enrichment-analysis was performed on highly ranked findings. Further characterization of the findings was conducted in 313 Dutch IMAGE children using the Developmental Coordination Disorder Questionnaire (DCD-Q). Results. Although none of the findings reached genome-wide significance, bioinformatics analysis of the top-ranked findings revealed enrichment of genes for motor neuropathy and amyotrophic lateral sclerosis. Genes involved in neurite outgrowth and muscle function were also enriched. Among the highest ranked genes were MAP2K5, involved in restless legs syndrome, and CHD6, causing motor coordination problems in mice. Further characterization of these findings using DCD-Q subscales found nominal association for 15 SNPs. Conclusions. Our findings provide clues about the aetiology of motor coordination problems, but replication studies in independent samples are necessary.",

author = "Fliers, {Ellen A.} and Vasquez, {Alejandro Arias} and Geert Poelmans and Nanda Rommelse and Marieke Altink and Cathelijne Buschgens and Philip Asherson and Tobias Banaschewski and Richard Ebstein and Michael Gill and Ana Miranda and Fernando Mulas and Oades, {Robert D.} and Herbert Roeyers and Aribert Rothenberger and Joseph Sergeant and Edmund Sonuga-Barke and Hans-Christoph Steinhausen and Faraone, {Stephen V.} and Buitelaar, {Jan K.} and Barbara Franke",

year = "2012",

month = mar,

doi = "10.3109/15622975.2011.560279",

language = "English",

volume = "13",

pages = "211 -- 222",

journal = "World Journal of Biological Psychiatry",

issn = "1814-1412",

publisher = "Taylor & Francis",

number = "3",

}

Fliers, EA, Vasquez, AA, Poelmans, G, Rommelse, N, Altink, M, Buschgens, C, Asherson, P, Banaschewski, T, Ebstein, R, Gill, M, Miranda, A, Mulas, F, Oades, RD, Roeyers, H, Rothenberger, A, Sergeant, J, Sonuga-Barke, E, Steinhausen, H-C, Faraone, SV, Buitelaar, JK & Franke, B 2012, 'Genome-wide association study of motor coordination problems in ADHD identifies genes for brain and muscle function', World Journal of Biological Psychiatry, vol. 13, no. 3, pp. 211 - 222. https://doi.org/10.3109/15622975.2011.560279

TY - JOUR

T1 - Genome-wide association study of motor coordination problems in ADHD identifies genes for brain and muscle function

AU - Fliers, Ellen A.

AU - Vasquez, Alejandro Arias

AU - Poelmans, Geert

AU - Rommelse, Nanda

AU - Altink, Marieke

AU - Buschgens, Cathelijne

AU - Asherson, Philip

AU - Banaschewski, Tobias

AU - Ebstein, Richard

AU - Gill, Michael

AU - Miranda, Ana

AU - Mulas, Fernando

AU - Oades, Robert D.

AU - Roeyers, Herbert

AU - Rothenberger, Aribert

AU - Sergeant, Joseph

AU - Sonuga-Barke, Edmund

AU - Steinhausen, Hans-Christoph

AU - Faraone, Stephen V.

AU - Buitelaar, Jan K.

AU - Franke, Barbara

PY - 2012/3

Y1 - 2012/3

N2 - Objectives. Motor coordination problems are frequent in children with attention deficit/hyperactivity disorder (ADHD). We performed a genome-wide association study to identify genes contributing to motor coordination problems, hypothesizing that the presence of such problems in children with ADHD may identify a sample of reduced genetic heterogeneity. Methods. Children with ADHD from the International Multicentre ADHD Genetic (IMAGE) study were evaluated with the Parental Account of Children's Symptoms. Genetic association testing was performed in PLINK on 890 probands with genome-wide genotyping data. Bioinformatics enrichment-analysis was performed on highly ranked findings. Further characterization of the findings was conducted in 313 Dutch IMAGE children using the Developmental Coordination Disorder Questionnaire (DCD-Q). Results. Although none of the findings reached genome-wide significance, bioinformatics analysis of the top-ranked findings revealed enrichment of genes for motor neuropathy and amyotrophic lateral sclerosis. Genes involved in neurite outgrowth and muscle function were also enriched. Among the highest ranked genes were MAP2K5, involved in restless legs syndrome, and CHD6, causing motor coordination problems in mice. Further characterization of these findings using DCD-Q subscales found nominal association for 15 SNPs. Conclusions. Our findings provide clues about the aetiology of motor coordination problems, but replication studies in independent samples are necessary.

AB - Objectives. Motor coordination problems are frequent in children with attention deficit/hyperactivity disorder (ADHD). We performed a genome-wide association study to identify genes contributing to motor coordination problems, hypothesizing that the presence of such problems in children with ADHD may identify a sample of reduced genetic heterogeneity. Methods. Children with ADHD from the International Multicentre ADHD Genetic (IMAGE) study were evaluated with the Parental Account of Children's Symptoms. Genetic association testing was performed in PLINK on 890 probands with genome-wide genotyping data. Bioinformatics enrichment-analysis was performed on highly ranked findings. Further characterization of the findings was conducted in 313 Dutch IMAGE children using the Developmental Coordination Disorder Questionnaire (DCD-Q). Results. Although none of the findings reached genome-wide significance, bioinformatics analysis of the top-ranked findings revealed enrichment of genes for motor neuropathy and amyotrophic lateral sclerosis. Genes involved in neurite outgrowth and muscle function were also enriched. Among the highest ranked genes were MAP2K5, involved in restless legs syndrome, and CHD6, causing motor coordination problems in mice. Further characterization of these findings using DCD-Q subscales found nominal association for 15 SNPs. Conclusions. Our findings provide clues about the aetiology of motor coordination problems, but replication studies in independent samples are necessary.

U2 - 10.3109/15622975.2011.560279

DO - 10.3109/15622975.2011.560279

M3 - Article

SN - 1814-1412

VL - 13

SP - 211

EP - 222

JO - World Journal of Biological Psychiatry

JF - World Journal of Biological Psychiatry

IS - 3

ER -

Genome-wide association study of motor coordination problems in ADHD identifies genes for brain and muscle function

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this