@article{00a08e7e01ba42f6a5c89d6ad3a0f129,
title = "Genome-wide association study of suicidal behaviour severity in mood disorders",
abstract = "Objective: Suicide is a major public health problem and it has a prominent genetic component. We performed a genome-wide association study (GWAS) of suicidal behaviour severity. Methods: Suicide behaviour severity was assessed within the Schedules for Clinical Assessment in Neuropsychiatry in our mood disorder sample (n = 3506) for the GWAS. We also performed polygenic risk score analyses to explore genetic sharing between suicidal behaviour severity and a number of phenotypes, including bipolar disorder, major depressive disorder, alcoholism, post-traumatic stress disorder, impulsivity, insomnia, educational attainment, loneliness, maltreatment, and amygdala volume. Results: We did not detect genome-wide significant findings at the single-marker or gene level. We report a number of suggestive single-marker and gene-based findings. Our polygenic risk score analyses did not yield significant findings with these phenotypes. Conclusions: Larger sample sizes are required to detect moderate effects.",
keywords = "Suicidality; genome-wide association study; bipolar disorder; major depressive disorder; suicidal behaviour severity",
author = "Zai, {Clement C.} and Chiara Fabbri and Hosang, {Georgina M.} and Zhang, {Ruo Su} and Emiko Koyama and {de Luca}, Vincenzo and Tiwari, {Arun K.} and Nicole King and John Strauss and Ian Jones and Lisa Jones and Gerome Breen and Farmer, {Anne E.} and Peter McGuffin and Vincent, {John B.} and Kennedy, {James L.} and Lewis, {Cathryn M.}",
note = "Funding Information: This work was supported by a joint grant from the Medical Research Council, UK and GlaxoSmithKline [G0701420]; by financial support from the NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King?s College London. The GENDEP study was funded by a European Commission Framework 6 grant, EC Contract Ref. [LSHB-CT-2003-503428]. GlaxoSmithKline funded the collection of the DeNt cohort of depression cases, the genotyping of all RADIANT cases (with the MRC), and both the collection and genotyping of the GSK-Munich cohort of depression cases. GMH was supported by Barts Charity [OGA007973] and International Bipolar Foundation. This project was supported by funding sources including: Canadian Institutes for Health Research [JLK (MOP-115097), JBV (MOP-84391), VdL (MOP-115689, MOP-119332)], Brain and Behaviour Research Foundation (NARSAD Young Investigator Awards) [AKT, CCZ], and CAMH Foundation [JLK, AKT, CCZ]. CF was supported by Fondazione Umberto Veronesi. The collection of the IOP and CA2 samples was supported by funding from GlaxoSmithKline. This work was also supported by funding sources and participating studies that contributed to the summary statistics data for the polygenic risk score analyses. In addition, the Substance Use Disorders Working Group of the Psychiatric Genomics Consortium (PGC-SUD) is supported by funds from NIDA and NIMH [MH109532] and, previously, with analyst support from NIAAA [U01AA008401 (COGA)]. All genotype and loneliness phenotype data were collected as part of the Health and Retirement Study (http://hrsonline.isr.umich.edu/). The Health and Retirement Study genetic data is sponsored by the National Institute on Aging [U01AG009740, RC2AG036495, and RC4AG039029] and was conducted by the University of Michigan. The authors would like to thank the funding sources and participating sites for the study samples. The authors also gratefully acknowledge the contributing studies and the participants in those studies without whom this effort would not be possible. Publisher Copyright: {\textcopyright} 2021 Informa UK Limited, trading as Taylor & Francis Group.",
year = "2021",
doi = "10.1080/15622975.2021.1907711",
language = "English",
volume = "22",
pages = "722--731",
journal = "World Journal of Biological Psychiatry",
issn = "1562-2975",
publisher = "Taylor & Francis",
number = "9",
}
