Genome-wide meta-analysis identifies new susceptibility loci for migraine

Verneri Anttila; Bendik S Winsvold; Padhraig Gormley; Tobias Kurth; Francesco Bettella; George McMahon; Mikko Kallela; Rainer Malik; Boukje de Vries; Gisela Terwindt; Sarah E Medland; Unda Todt; Wendy L McArdle; Lydia Quaye; Markku Koiranen; M Arfan Ikram; Terho Lehtimäki; Anine H Stam; Lannie Ligthart; Juho Wedenoja; Ian Dunham; Benjamin M Neale; Priit Palta; Eija Hamalainen; Markus Schürks; Lynda M Rose; Julie E Buring; Paul M Ridker; Stacy Steinberg; Hreinn Stefansson; Finnbogi Jakobsson; Debbie A Lawlor; David M Evans; Susan M Ring; Markus Färkkilä; Ville Artto; Mari A Kaunisto; Tobias Freilinger; Jean Schoenen; Rune R Frants; Nadine Pelzer; Claudia M Weller; Ronald Zielman; Andrew C Heath; Pamela A F Madden; Grant W Montgomery; Nicholas G Martin; Guntram Borck; Frances M K Williams; Lynn Cherkas; North American Brain Expression Consortium

doi:10.1038/ng.2676

Genome-wide meta-analysis identifies new susceptibility loci for migraine

Verneri Anttila, Bendik S Winsvold, Padhraig Gormley, Tobias Kurth, Francesco Bettella, George McMahon, Mikko Kallela, Rainer Malik, Boukje de Vries, Gisela Terwindt, Sarah E Medland, Unda Todt, Wendy L McArdle, Lydia Quaye, Markku Koiranen, M Arfan Ikram, Terho Lehtimäki, Anine H Stam, Lannie Ligthart, Juho WedenojaIan Dunham, Benjamin M Neale, Priit Palta, Eija Hamalainen, Markus Schürks, Lynda M Rose, Julie E Buring, Paul M Ridker, Stacy Steinberg, Hreinn Stefansson, Finnbogi Jakobsson, Debbie A Lawlor, David M Evans, Susan M Ring, Markus Färkkilä, Ville Artto, Mari A Kaunisto, Tobias Freilinger, Jean Schoenen, Rune R Frants, Nadine Pelzer, Claudia M Weller, Ronald Zielman, Andrew C Heath, Pamela A F Madden, Grant W Montgomery, Nicholas G Martin, Guntram Borck, Frances M K Williams, Lynn Cherkas, North American Brain Expression Consortium

Wellcome Sanger Institute

Research output: Contribution to journal › Article › peer-review

331 Citations (Scopus)

Abstract

Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P < 5 × 10−8). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.

Original language	English
Article number	N/A
Pages (from-to)	912-917
Number of pages	6
Journal	Nature Genetics
Volume	45
Issue number	8
DOIs	https://doi.org/10.1038/ng.2676
Publication status	Published - Aug 2013

Keywords

Cerebellum
Computational Biology
Frontal Lobe
Genetic Loci
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Migraine Disorders
Polymorphism, Single Nucleotide
Quantitative Trait Loci

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Anttila, V., Winsvold, B. S., Gormley, P., Kurth, T., Bettella, F., McMahon, G., Kallela, M., Malik, R., de Vries, B., Terwindt, G., Medland, S. E., Todt, U., McArdle, W. L., Quaye, L., Koiranen, M., Ikram, M. A., Lehtimäki, T., Stam, A. H., Ligthart, L., ... North American Brain Expression Consortium (2013). Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nature Genetics, 45(8), 912-917. Article N/A. https://doi.org/10.1038/ng.2676

@article{62dc896c98f046489eacb8e0bbf21276,

title = "Genome-wide meta-analysis identifies new susceptibility loci for migraine",

abstract = "Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P < 5 × 10−8). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.",

keywords = "Cerebellum, Computational Biology, Frontal Lobe, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Migraine Disorders, Polymorphism, Single Nucleotide, Quantitative Trait Loci",

author = "Verneri Anttila and Winsvold, {Bendik S} and Padhraig Gormley and Tobias Kurth and Francesco Bettella and George McMahon and Mikko Kallela and Rainer Malik and {de Vries}, Boukje and Gisela Terwindt and Medland, {Sarah E} and Unda Todt and McArdle, {Wendy L} and Lydia Quaye and Markku Koiranen and Ikram, {M Arfan} and Terho Lehtim{\"a}ki and Stam, {Anine H} and Lannie Ligthart and Juho Wedenoja and Ian Dunham and Neale, {Benjamin M} and Priit Palta and Eija Hamalainen and Markus Sch{\"u}rks and Rose, {Lynda M} and Buring, {Julie E} and Ridker, {Paul M} and Stacy Steinberg and Hreinn Stefansson and Finnbogi Jakobsson and Lawlor, {Debbie A} and Evans, {David M} and Ring, {Susan M} and Markus F{\"a}rkkil{\"a} and Ville Artto and Kaunisto, {Mari A} and Tobias Freilinger and Jean Schoenen and Frants, {Rune R} and Nadine Pelzer and Weller, {Claudia M} and Ronald Zielman and Heath, {Andrew C} and Madden, {Pamela A F} and Montgomery, {Grant W} and Martin, {Nicholas G} and Guntram Borck and Williams, {Frances M K} and Lynn Cherkas and {North American Brain Expression Consortium}",

year = "2013",

month = aug,

doi = "10.1038/ng.2676",

language = "English",

volume = "45",

pages = "912--917",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "8",

}

Anttila, V, Winsvold, BS, Gormley, P, Kurth, T, Bettella, F, McMahon, G, Kallela, M, Malik, R, de Vries, B, Terwindt, G, Medland, SE, Todt, U, McArdle, WL, Quaye, L, Koiranen, M, Ikram, MA, Lehtimäki, T, Stam, AH, Ligthart, L, Wedenoja, J, Dunham, I, Neale, BM, Palta, P, Hamalainen, E, Schürks, M, Rose, LM, Buring, JE, Ridker, PM, Steinberg, S, Stefansson, H, Jakobsson, F, Lawlor, DA, Evans, DM, Ring, SM, Färkkilä, M, Artto, V, Kaunisto, MA, Freilinger, T, Schoenen, J, Frants, RR, Pelzer, N, Weller, CM, Zielman, R, Heath, AC, Madden, PAF, Montgomery, GW, Martin, NG, Borck, G, Williams, FMK , Cherkas, L & North American Brain Expression Consortium 2013, 'Genome-wide meta-analysis identifies new susceptibility loci for migraine', Nature Genetics, vol. 45, no. 8, N/A, pp. 912-917. https://doi.org/10.1038/ng.2676

TY - JOUR

T1 - Genome-wide meta-analysis identifies new susceptibility loci for migraine

AU - Anttila, Verneri

AU - Winsvold, Bendik S

AU - Gormley, Padhraig

AU - Kurth, Tobias

AU - Bettella, Francesco

AU - McMahon, George

AU - Kallela, Mikko

AU - Malik, Rainer

AU - de Vries, Boukje

AU - Terwindt, Gisela

AU - Medland, Sarah E

AU - Todt, Unda

AU - McArdle, Wendy L

AU - Quaye, Lydia

AU - Koiranen, Markku

AU - Ikram, M Arfan

AU - Lehtimäki, Terho

AU - Stam, Anine H

AU - Ligthart, Lannie

AU - Wedenoja, Juho

AU - Dunham, Ian

AU - Neale, Benjamin M

AU - Palta, Priit

AU - Hamalainen, Eija

AU - Schürks, Markus

AU - Rose, Lynda M

AU - Buring, Julie E

AU - Ridker, Paul M

AU - Steinberg, Stacy

AU - Stefansson, Hreinn

AU - Jakobsson, Finnbogi

AU - Lawlor, Debbie A

AU - Evans, David M

AU - Ring, Susan M

AU - Färkkilä, Markus

AU - Artto, Ville

AU - Kaunisto, Mari A

AU - Freilinger, Tobias

AU - Schoenen, Jean

AU - Frants, Rune R

AU - Pelzer, Nadine

AU - Weller, Claudia M

AU - Zielman, Ronald

AU - Heath, Andrew C

AU - Madden, Pamela A F

AU - Montgomery, Grant W

AU - Martin, Nicholas G

AU - Borck, Guntram

AU - Williams, Frances M K

AU - Cherkas, Lynn

AU - North American Brain Expression Consortium

PY - 2013/8

Y1 - 2013/8

N2 - Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P < 5 × 10−8). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.

AB - Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P < 5 × 10−8). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.

KW - Cerebellum

KW - Computational Biology

KW - Frontal Lobe

KW - Genetic Loci

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Humans

KW - Migraine Disorders

KW - Polymorphism, Single Nucleotide

KW - Quantitative Trait Loci

U2 - 10.1038/ng.2676

DO - 10.1038/ng.2676

M3 - Article

C2 - 23793025

SN - 1061-4036

VL - 45

SP - 912

EP - 917

JO - Nature Genetics

JF - Nature Genetics

IS - 8

M1 - N/A

ER -

Genome-wide meta-analysis identifies new susceptibility loci for migraine

Abstract

Keywords

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