Genome-wide significant association between a 'negative mood delusions' dimension in bipolar disorder and genetic variation on chromosome 3q26.1

S Meier; M Mattheisen; E Vassos; J Strohmaier; J Treutlein; F Josef; R Breuer; F Degenhardt; T W M??hleisen; B M??ller-myhsok; M Steffens; C Schmael; F J Mcmahon; John R Kelsoe; Tiffany A Greenwood; Caroline M Nievergelt; Thomas B Barrett; Rebecca Mckinney; Paul D Shilling; Nicholas J Schork; Erin N Smith; Cinnamon S Bloss; John Nurnberger; Howard J Edenberg; Tatiana Foroud; Daniel L Koller; Elliot S Gershon; Chun-yu Liu; Judith A Badner; William Scheftner; William B Lawson; Evaristus A Nwulia; Maria Hipolito; William Coryell; John Rice; William Byerley; Francis Mcmahon; David Tw Chen; Thomas G Schulze; Wade Berrettini; James B Potash; Peter P Zandi; Pamela B Mahon; Melvin Mcinnis; David Craig; Szabolcs Szelinger; M M N??then; S Cichon; T G Schulze; M Rietschel

doi:10.1038/tp.2012.81

Genome-wide significant association between a 'negative mood delusions' dimension in bipolar disorder and genetic variation on chromosome 3q26.1

S Meier, M Mattheisen, E Vassos, J Strohmaier, J Treutlein, F Josef, R Breuer, F Degenhardt, T W M??hleisen, B M??ller-myhsok, M Steffens, C Schmael, F J Mcmahon, John R Kelsoe, Tiffany A Greenwood, Caroline M Nievergelt, Thomas B Barrett, Rebecca Mckinney, Paul D Shilling, Nicholas J SchorkErin N Smith, Cinnamon S Bloss, John Nurnberger, Howard J Edenberg, Tatiana Foroud, Daniel L Koller, Elliot S Gershon, Chun-yu Liu, Judith A Badner, William Scheftner, William B Lawson, Evaristus A Nwulia, Maria Hipolito, William Coryell, John Rice, William Byerley, Francis Mcmahon, David Tw Chen, Thomas G Schulze, Wade Berrettini, James B Potash, Peter P Zandi, Pamela B Mahon, Melvin Mcinnis, David Craig, Szabolcs Szelinger, M M N??then, S Cichon, T G Schulze, M Rietschel

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Abstract

Research suggests that clinical symptom dimensions may be more useful in delineating the genetics of bipolar disorder (BD) than standard diagnostic models. To date, no study has applied this concept to data from genome-wide association studies (GWAS). We performed a GWAS of factor dimensions in 927 clinically well-characterized BD patients of German ancestry. Rs9875793, which is located in an intergenic region of 3q26.1 and in the vicinity of the solute carrier family 2 (facilitated glucose transporter), member 2 gene (SLC2A2), was significantly associated with the factor analysis-derived dimension ‘negative mood delusions’ (n=927; P=4.65 × 10−8, odds ratio (OR)=2.66). This dimension was comprised of the symptoms delusions of poverty, delusions of guilt and nihilistic delusions. In case–control analyses, significant association with the G allele of rs9875793 was only observed in the subgroup of BD patients who displayed symptoms of ‘negative mood delusions’ (allelic χ2 model: PG=0.0001, OR=1.92; item present, n=89). Further support for the hypothesis that rs9875793 is associated with BD in patients displaying ‘negative mood delusions’ symptom, such as delusions of guilt, was obtained from an European American sample (GAIN/TGEN), which included 1247 BD patients and 1434 controls (PEA=0.028, OR=1.27).

Original language	English
Article number	e165
Pages (from-to)	N/A
Number of pages	6
Journal	Translational psychiatry
Volume	2
Issue number	N/A
Early online date	25 Sept 2013
DOIs	https://doi.org/10.1038/tp.2012.81
Publication status	Published - 2013

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10.1038/tp.2012.81

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Meier, S., Mattheisen, M., Vassos, E., Strohmaier, J., Treutlein, J., Josef, F., Breuer, R., Degenhardt, F., M??hleisen, T. W., M??ller-myhsok, B., Steffens, M., Schmael, C., Mcmahon, F. J., Kelsoe, J. R., Greenwood, T. A., Nievergelt, C. M., Barrett, T. B., Mckinney, R., Shilling, P. D., ... Rietschel, M. (2013). Genome-wide significant association between a 'negative mood delusions' dimension in bipolar disorder and genetic variation on chromosome 3q26.1. Translational psychiatry, 2(N/A), N/A. Article e165. https://doi.org/10.1038/tp.2012.81

@article{3e6e6c17fee9419d8c9ba966d6789b3e,

title = "Genome-wide significant association between a 'negative mood delusions' dimension in bipolar disorder and genetic variation on chromosome 3q26.1",

abstract = "Research suggests that clinical symptom dimensions may be more useful in delineating the genetics of bipolar disorder (BD) than standard diagnostic models. To date, no study has applied this concept to data from genome-wide association studies (GWAS). We performed a GWAS of factor dimensions in 927 clinically well-characterized BD patients of German ancestry. Rs9875793, which is located in an intergenic region of 3q26.1 and in the vicinity of the solute carrier family 2 (facilitated glucose transporter), member 2 gene (SLC2A2), was significantly associated with the factor analysis-derived dimension {\textquoteleft}negative mood delusions{\textquoteright} (n=927; P=4.65 × 10−8, odds ratio (OR)=2.66). This dimension was comprised of the symptoms delusions of poverty, delusions of guilt and nihilistic delusions. In case–control analyses, significant association with the G allele of rs9875793 was only observed in the subgroup of BD patients who displayed symptoms of {\textquoteleft}negative mood delusions{\textquoteright} (allelic χ2 model: PG=0.0001, OR=1.92; item present, n=89). Further support for the hypothesis that rs9875793 is associated with BD in patients displaying {\textquoteleft}negative mood delusions{\textquoteright} symptom, such as delusions of guilt, was obtained from an European American sample (GAIN/TGEN), which included 1247 BD patients and 1434 controls (PEA=0.028, OR=1.27).",

author = "S Meier and M Mattheisen and E Vassos and J Strohmaier and J Treutlein and F Josef and R Breuer and F Degenhardt and M??hleisen, {T W} and B M??ller-myhsok and M Steffens and C Schmael and Mcmahon, {F J} and Kelsoe, {John R} and Greenwood, {Tiffany A} and Nievergelt, {Caroline M} and Barrett, {Thomas B} and Rebecca Mckinney and Shilling, {Paul D} and Schork, {Nicholas J} and Smith, {Erin N} and Bloss, {Cinnamon S} and John Nurnberger and Edenberg, {Howard J} and Tatiana Foroud and Koller, {Daniel L} and Gershon, {Elliot S} and Chun-yu Liu and Badner, {Judith A} and William Scheftner and Lawson, {William B} and Nwulia, {Evaristus A} and Maria Hipolito and William Coryell and John Rice and William Byerley and Francis Mcmahon and Chen, {David Tw} and Schulze, {Thomas G} and Wade Berrettini and Potash, {James B} and Zandi, {Peter P} and Mahon, {Pamela B} and Melvin Mcinnis and David Craig and Szabolcs Szelinger and N??then, {M M} and S Cichon and Schulze, {T G} and M Rietschel",

year = "2013",

doi = "10.1038/tp.2012.81",

language = "English",

volume = "2",

pages = "N/A",

journal = "Translational psychiatry",

issn = "2158-3188",

publisher = "Nature Publishing Group",

number = "N/A",

}

Meier, S, Mattheisen, M, Vassos, E, Strohmaier, J, Treutlein, J, Josef, F, Breuer, R, Degenhardt, F, M??hleisen, TW, M??ller-myhsok, B, Steffens, M, Schmael, C, Mcmahon, FJ, Kelsoe, JR, Greenwood, TA, Nievergelt, CM, Barrett, TB, Mckinney, R, Shilling, PD, Schork, NJ, Smith, EN, Bloss, CS, Nurnberger, J, Edenberg, HJ, Foroud, T, Koller, DL, Gershon, ES, Liu, C, Badner, JA, Scheftner, W, Lawson, WB, Nwulia, EA, Hipolito, M, Coryell, W, Rice, J, Byerley, W, Mcmahon, F, Chen, DT, Schulze, TG, Berrettini, W, Potash, JB, Zandi, PP, Mahon, PB, Mcinnis, M, Craig, D, Szelinger, S, N??then, MM, Cichon, S, Schulze, TG & Rietschel, M 2013, 'Genome-wide significant association between a 'negative mood delusions' dimension in bipolar disorder and genetic variation on chromosome 3q26.1', Translational psychiatry, vol. 2, no. N/A, e165, pp. N/A. https://doi.org/10.1038/tp.2012.81

TY - JOUR

T1 - Genome-wide significant association between a 'negative mood delusions' dimension in bipolar disorder and genetic variation on chromosome 3q26.1

AU - Meier, S

AU - Mattheisen, M

AU - Vassos, E

AU - Strohmaier, J

AU - Treutlein, J

AU - Josef, F

AU - Breuer, R

AU - Degenhardt, F

AU - M??hleisen, T W

AU - M??ller-myhsok, B

AU - Steffens, M

AU - Schmael, C

AU - Mcmahon, F J

AU - Kelsoe, John R

AU - Greenwood, Tiffany A

AU - Nievergelt, Caroline M

AU - Barrett, Thomas B

AU - Mckinney, Rebecca

AU - Shilling, Paul D

AU - Schork, Nicholas J

AU - Smith, Erin N

AU - Bloss, Cinnamon S

AU - Nurnberger, John

AU - Edenberg, Howard J

AU - Foroud, Tatiana

AU - Koller, Daniel L

AU - Gershon, Elliot S

AU - Liu, Chun-yu

AU - Badner, Judith A

AU - Scheftner, William

AU - Lawson, William B

AU - Nwulia, Evaristus A

AU - Hipolito, Maria

AU - Coryell, William

AU - Rice, John

AU - Byerley, William

AU - Mcmahon, Francis

AU - Chen, David Tw

AU - Schulze, Thomas G

AU - Berrettini, Wade

AU - Potash, James B

AU - Zandi, Peter P

AU - Mahon, Pamela B

AU - Mcinnis, Melvin

AU - Craig, David

AU - Szelinger, Szabolcs

AU - N??then, M M

AU - Cichon, S

AU - Schulze, T G

AU - Rietschel, M

PY - 2013

Y1 - 2013

N2 - Research suggests that clinical symptom dimensions may be more useful in delineating the genetics of bipolar disorder (BD) than standard diagnostic models. To date, no study has applied this concept to data from genome-wide association studies (GWAS). We performed a GWAS of factor dimensions in 927 clinically well-characterized BD patients of German ancestry. Rs9875793, which is located in an intergenic region of 3q26.1 and in the vicinity of the solute carrier family 2 (facilitated glucose transporter), member 2 gene (SLC2A2), was significantly associated with the factor analysis-derived dimension ‘negative mood delusions’ (n=927; P=4.65 × 10−8, odds ratio (OR)=2.66). This dimension was comprised of the symptoms delusions of poverty, delusions of guilt and nihilistic delusions. In case–control analyses, significant association with the G allele of rs9875793 was only observed in the subgroup of BD patients who displayed symptoms of ‘negative mood delusions’ (allelic χ2 model: PG=0.0001, OR=1.92; item present, n=89). Further support for the hypothesis that rs9875793 is associated with BD in patients displaying ‘negative mood delusions’ symptom, such as delusions of guilt, was obtained from an European American sample (GAIN/TGEN), which included 1247 BD patients and 1434 controls (PEA=0.028, OR=1.27).

AB - Research suggests that clinical symptom dimensions may be more useful in delineating the genetics of bipolar disorder (BD) than standard diagnostic models. To date, no study has applied this concept to data from genome-wide association studies (GWAS). We performed a GWAS of factor dimensions in 927 clinically well-characterized BD patients of German ancestry. Rs9875793, which is located in an intergenic region of 3q26.1 and in the vicinity of the solute carrier family 2 (facilitated glucose transporter), member 2 gene (SLC2A2), was significantly associated with the factor analysis-derived dimension ‘negative mood delusions’ (n=927; P=4.65 × 10−8, odds ratio (OR)=2.66). This dimension was comprised of the symptoms delusions of poverty, delusions of guilt and nihilistic delusions. In case–control analyses, significant association with the G allele of rs9875793 was only observed in the subgroup of BD patients who displayed symptoms of ‘negative mood delusions’ (allelic χ2 model: PG=0.0001, OR=1.92; item present, n=89). Further support for the hypothesis that rs9875793 is associated with BD in patients displaying ‘negative mood delusions’ symptom, such as delusions of guilt, was obtained from an European American sample (GAIN/TGEN), which included 1247 BD patients and 1434 controls (PEA=0.028, OR=1.27).

U2 - 10.1038/tp.2012.81

DO - 10.1038/tp.2012.81

M3 - Article

SN - 2158-3188

VL - 2

SP - N/A

JO - Translational psychiatry

JF - Translational psychiatry

IS - N/A

M1 - e165

ER -

Genome-wide significant association between a 'negative mood delusions' dimension in bipolar disorder and genetic variation on chromosome 3q26.1

Abstract

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