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Genome-wide association analysis identifies 13 new risk loci for schizophrenia

Research output: Contribution to journalArticle

Stephan Ripke, Colm O'dushlaine, Kimberly Chambert, Jennifer L Moran, Anna K K??hler, Susanne Akterin, Sarah E Bergen, Ann L Collins, James J Crowley, Menachem Fromer, Yunjung Kim, Sang Hong Lee, Patrik K E Magnusson, Nick Sanchez, Eli A Stahl, Stephanie Williams, Naomi R Wray, Kai Xia, Francesco Bettella, Anders D Borglum & 15 more Brendan K Bulik-sullivan, Paul Cormican, Nick Craddock, Christiaan De Leeuw, Naser Durmishi, Michael Gill, Kuang Lin, Benjamin M Neale, John Powell, Brien P Riley, James T Walters, Multicenter Genetic Studies of Schizophrenia Consortium, Psychosis Endophenotypes International Consortium, Wellcome Trust Case Consortium 2, Shaun Purcell

Original languageEnglish
Pages (from-to)1150-1159
Number of pages10
JournalNature Genetics
Volume45
Issue number10
DOIs
PublishedOct 2013

King's Authors

Abstract

Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and 6,243 controls) followed by meta-analysis with previous schizophrenia GWAS (8,832 cases and 12,067 controls) and finally by replication of SNPs in 168 genomic regions in independent samples (7,413 cases, 19,762 controls and 581 parent-offspring trios). We identified 22 loci associated at genome-wide significance; 13 of these are new, and 1 was previously implicated in bipolar disorder. Examination of candidate genes at these loci suggests the involvement of neuronal calcium signaling. We estimate that 8,300 independent, mostly common SNPs (95% credible interval of 6,300–10,200 SNPs) contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability. Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder.

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