Genotyping of the Alzheimer's Disease Genome-Wide Association Study Index Single Nucleotide Polymorphisms in the Brains for Dementia Research Cohort

Keeley J. Brookes; George McConnell; Kirsty Williams; Sultan Chaudhury; Gaganjit Madhan; Tulsi Patel; Christopher Turley; Tamar Guetta-Baranes; Jose Bras; Rita Guerreiro; John Hardy; Paul T. Francis; Kevin Morgan

doi:10.3233/JAD-180191

Genotyping of the Alzheimer's Disease Genome-Wide Association Study Index Single Nucleotide Polymorphisms in the Brains for Dementia Research Cohort

Keeley J. Brookes^*, George McConnell, Kirsty Williams, Sultan Chaudhury, Gaganjit Madhan, Tulsi Patel, Christopher Turley, Tamar Guetta-Baranes, Jose Bras, Rita Guerreiro, John Hardy, Paul T. Francis, Kevin Morgan

^*Corresponding author for this work

Wolfson SPaRC

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The Brains for Dementia Research project is a recently established longitudinal cohort which aims to provide brain tissue for research purposes from neuropathologically defined samples. Here we present the findings from our analysis on the 19 established GWAS index SNPs for Alzheimer's disease, in order to demonstrate if the BDR sample also displays association to these variants. A highly significant association of the APOE ϵ4 allele was identified (p = 3.99×10 -12). Association tests for the 19 GWAS SNPs found that although no SNPs survive multiple testing, nominal significant findings were detected and concordance with the Lambert et al. GWAS meta-analysis was observed.

Original language	English
Pages (from-to)	355-362
Number of pages	8
Journal	Journal of Alzheimer's Disease
Volume	64
Issue number	2
DOIs	https://doi.org/10.3233/JAD-180191
Publication status	Published - 19 Jun 2018

Keywords

Alzheimer's disease
association
Brains for Dementia Research
genome-wide association study
single nucleotide polymorphisms

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10.3233/JAD-180191

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Brookes, K. J., McConnell, G., Williams, K., Chaudhury, S., Madhan, G., Patel, T., Turley, C., Guetta-Baranes, T., Bras, J., Guerreiro, R., Hardy, J., Francis, P. T., & Morgan, K. (2018). Genotyping of the Alzheimer's Disease Genome-Wide Association Study Index Single Nucleotide Polymorphisms in the Brains for Dementia Research Cohort. Journal of Alzheimer's Disease, 64(2), 355-362. https://doi.org/10.3233/JAD-180191

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abstract = "The Brains for Dementia Research project is a recently established longitudinal cohort which aims to provide brain tissue for research purposes from neuropathologically defined samples. Here we present the findings from our analysis on the 19 established GWAS index SNPs for Alzheimer's disease, in order to demonstrate if the BDR sample also displays association to these variants. A highly significant association of the APOE ϵ4 allele was identified (p = 3.99×10 -12). Association tests for the 19 GWAS SNPs found that although no SNPs survive multiple testing, nominal significant findings were detected and concordance with the Lambert et al. GWAS meta-analysis was observed.",

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author = "Brookes, {Keeley J.} and George McConnell and Kirsty Williams and Sultan Chaudhury and Gaganjit Madhan and Tulsi Patel and Christopher Turley and Tamar Guetta-Baranes and Jose Bras and Rita Guerreiro and John Hardy and Francis, {Paul T.} and Kevin Morgan",

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Brookes, KJ, McConnell, G, Williams, K, Chaudhury, S, Madhan, G, Patel, T, Turley, C, Guetta-Baranes, T, Bras, J, Guerreiro, R, Hardy, J, Francis, PT & Morgan, K 2018, 'Genotyping of the Alzheimer's Disease Genome-Wide Association Study Index Single Nucleotide Polymorphisms in the Brains for Dementia Research Cohort', Journal of Alzheimer's Disease, vol. 64, no. 2, pp. 355-362. https://doi.org/10.3233/JAD-180191

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T1 - Genotyping of the Alzheimer's Disease Genome-Wide Association Study Index Single Nucleotide Polymorphisms in the Brains for Dementia Research Cohort

AU - Brookes, Keeley J.

AU - McConnell, George

AU - Williams, Kirsty

AU - Chaudhury, Sultan

AU - Madhan, Gaganjit

AU - Patel, Tulsi

AU - Turley, Christopher

AU - Guetta-Baranes, Tamar

AU - Bras, Jose

AU - Guerreiro, Rita

AU - Hardy, John

AU - Francis, Paul T.

AU - Morgan, Kevin

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AB - The Brains for Dementia Research project is a recently established longitudinal cohort which aims to provide brain tissue for research purposes from neuropathologically defined samples. Here we present the findings from our analysis on the 19 established GWAS index SNPs for Alzheimer's disease, in order to demonstrate if the BDR sample also displays association to these variants. A highly significant association of the APOE ϵ4 allele was identified (p = 3.99×10 -12). Association tests for the 19 GWAS SNPs found that although no SNPs survive multiple testing, nominal significant findings were detected and concordance with the Lambert et al. GWAS meta-analysis was observed.

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KW - association

KW - Brains for Dementia Research

KW - genome-wide association study

KW - single nucleotide polymorphisms

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DO - 10.3233/JAD-180191

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VL - 64

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JF - Journal of Alzheimer's Disease

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Genotyping of the Alzheimer's Disease Genome-Wide Association Study Index Single Nucleotide Polymorphisms in the Brains for Dementia Research Cohort

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Keywords

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