TY - JOUR
T1 - Getting to the end of RNA: Structural analysis of protein recognition of 5 ' and 3 ' termini
AU - Curry, Stephen
AU - Kotik-Kogan, Olga
AU - Conte, Maria R.
AU - Brick, Peter
PY - 2009/9
Y1 - 2009/9
N2 - The specific recognition by proteins of the 5' and 3' ends of RNA molecules is an important facet of many cellular processes, including RNA maturation, regulation of translation initiation and control of gene expression by degradation and RNA interference. The aim of this review is to survey recent structural analyses of protein binding domains that specifically bind to the extreme 5' or 3' termini of RNA. For reasons of space and because their interactions are also governed by catalytic considerations, we have excluded enzymes that modify the 5' and 3' extremities of RNA. It is clear that there is enormous structural diversity among the proteins that have evolved to bind to the ends of RNA molecules. Moreover, they commonly exhibit conformational flexibility that appears to be important for binding and regulation of the interaction. This flexibility has sometimes complicated the interpretation of structural results and presents significant challenges for future investigations. (C) 2009 Elsevier B.V. All rights reserved.
AB - The specific recognition by proteins of the 5' and 3' ends of RNA molecules is an important facet of many cellular processes, including RNA maturation, regulation of translation initiation and control of gene expression by degradation and RNA interference. The aim of this review is to survey recent structural analyses of protein binding domains that specifically bind to the extreme 5' or 3' termini of RNA. For reasons of space and because their interactions are also governed by catalytic considerations, we have excluded enzymes that modify the 5' and 3' extremities of RNA. It is clear that there is enormous structural diversity among the proteins that have evolved to bind to the ends of RNA molecules. Moreover, they commonly exhibit conformational flexibility that appears to be important for binding and regulation of the interaction. This flexibility has sometimes complicated the interpretation of structural results and presents significant challenges for future investigations. (C) 2009 Elsevier B.V. All rights reserved.
U2 - 10.1016/j.bbagrm.2009.07.003
DO - 10.1016/j.bbagrm.2009.07.003
M3 - Literature review
VL - 1789
SP - 653
EP - 666
JO - Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms
JF - Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms
IS - 9-10
ER -