Giant Cell Tumour and Central Giant Cell Reparative Granuloma of the Skull: do These Represent Ends of a Spectrum? A Case Report and Literature Review

Sonia Saw, Nick Thomas, Michael J. Gleeson, Istvan Bodi, Steve Connor, Tibor Hortobagyi

    Research output: Contribution to journalArticlepeer-review

    23 Citations (Scopus)

    Abstract

    Giant cell tumour (GCT) of bone is an uncommon primary bone neoplasm typically occurring at the epiphyses of long bones in young adults. They are osteolytic neoplasms with approximate local recurrence rates of 25%, and 2% of patients develop pulmonary metastases. These tumours appear very rarely in the skull, with those few reported cases arising predominantly in the sphenoid and occasionally the temporal bones. They demonstrate benign histological features, but are locally aggressive and surgical excision is the treatment of choice. It is widely believed that giant cell tumours should be distinguished from other giant cell lesions, importantly central giant cell reparative granulomata (CGCG) which are thought to have a lower recurrence rate and for which no cases of malignant transformation or metastases have been reported. Investigators have noted that giant cell lesions in the skull bones may be unique and that GCT and CGCG may be part of a spectrum of a single disease process. We present a case of a giant cell tumour of the temporal bone which illustrates and re-emphasises this concept and review the literature on these lesions.
    Original languageEnglish
    Pages (from-to)291 - 295
    Number of pages5
    JournalPATHOLOGY ONCOLOGY RESEARCH
    Volume15
    Issue number2
    DOIs
    Publication statusPublished - Jun 2009

    Fingerprint

    Dive into the research topics of 'Giant Cell Tumour and Central Giant Cell Reparative Granuloma of the Skull: do These Represent Ends of a Spectrum? A Case Report and Literature Review'. Together they form a unique fingerprint.

    Cite this