King's College London

Research portal

GIFTed Demons: deformable image registration with local structure-preserving regularization using supervoxels for liver applications

Research output: Contribution to journalArticle

Bartłomiej W Papież, James M Franklin, Mattias P Heinrich, Fergus V Gleeson, Michael Brady, Julia A Schnabel

Original languageEnglish
Pages (from-to)024001
JournalJournal of medical imaging (Bellingham, Wash.)
Issue number2
Early online date4 Apr 2018
Publication statusE-pub ahead of print - 4 Apr 2018

King's Authors


Deformable image registration, a key component of motion correction in medical imaging, needs to be efficient and provides plausible spatial transformations that reliably approximate biological aspects of complex human organ motion. Standard approaches, such as Demons registration, mostly use Gaussian regularization for organ motion, which, though computationally efficient, rule out their application to intrinsically more complex organ motions, such as sliding interfaces. We propose regularization of motion based on supervoxels, which provides an integrated discontinuity preserving prior for motions, such as sliding. More precisely, we replace Gaussian smoothing by fast, structure-preserving, guided filtering to provide efficient, locally adaptive regularization of the estimated displacement field. We illustrate the approach by applying it to estimate sliding motions at lung and liver interfaces on challenging four-dimensional computed tomography (CT) and dynamic contrast-enhanced magnetic resonance imaging datasets. The results show that guided filter-based regularization improves the accuracy of lung and liver motion correction as compared to Gaussian smoothing. Furthermore, our framework achieves state-of-the-art results on a publicly available CT liver dataset.

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454