Gill cell culture systems as models for aquatic environmental monitoring

Nic R. Bury; Sabine Schnell; Christer Hogstrand

doi:10.1242/jeb.095430

Gill cell culture systems as models for aquatic environmental monitoring

Nic R. Bury, Sabine Schnell, Christer Hogstrand^*

^*Corresponding author for this work

Nutritional Sciences

King's College London

Research output: Contribution to journal › Literature review › peer-review

58 Citations (Scopus)

Abstract

A vast number of chemicals require environmental safety assessments for market authorisation. To ensure acceptable water quality, effluents and natural waters are monitored for their potential harmful effects. Tests for market authorisation and environmental monitoring usually involve the use of large numbers of organisms and, for ethical, cost and logistic reasons, there is a drive to develop alternative methods that can predict toxicity to fish without the need to expose any animals. There is therefore a great interest in the potential to use cultured fish cells in chemical toxicity testing. This review summarises the advances made in the area and focuses in particular on a system of cultured fish gill cells grown into an epithelium that permits direct treatment with water samples.

Original language	English
Pages (from-to)	639-650
Number of pages	12
Journal	Journal of Experimental Biology
Volume	217
Issue number	5
DOIs	https://doi.org/10.1242/jeb.095430
Publication status	Published - Mar 2014

Keywords

FIGCS
Biomonitoring
Environmental risk assessment
Fish
In vitro
Toxicology
WATER RAINBOW-TROUT
MITOCHONDRIA-RICH CELLS
O-DEETHYLASE INDUCTION
BLUEGILL BF-2 CELLS
IN-VITRO METHOD
FRESH-WATER
ONCORHYNCHUS-MYKISS
EPITHELIAL-CELLS
FISH GILL
INVITRO CYTOTOXICITY

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1242/jeb.095430

Cite this

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title = "Gill cell culture systems as models for aquatic environmental monitoring",

abstract = "A vast number of chemicals require environmental safety assessments for market authorisation. To ensure acceptable water quality, effluents and natural waters are monitored for their potential harmful effects. Tests for market authorisation and environmental monitoring usually involve the use of large numbers of organisms and, for ethical, cost and logistic reasons, there is a drive to develop alternative methods that can predict toxicity to fish without the need to expose any animals. There is therefore a great interest in the potential to use cultured fish cells in chemical toxicity testing. This review summarises the advances made in the area and focuses in particular on a system of cultured fish gill cells grown into an epithelium that permits direct treatment with water samples.",

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author = "Bury, {Nic R.} and Sabine Schnell and Christer Hogstrand",

year = "2014",

month = mar,

doi = "10.1242/jeb.095430",

language = "English",

volume = "217",

pages = "639--650",

journal = "Journal of Experimental Biology",

issn = "0022-0949",

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number = "5",

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TY - JOUR

T1 - Gill cell culture systems as models for aquatic environmental monitoring

AU - Bury, Nic R.

AU - Schnell, Sabine

AU - Hogstrand, Christer

PY - 2014/3

Y1 - 2014/3

N2 - A vast number of chemicals require environmental safety assessments for market authorisation. To ensure acceptable water quality, effluents and natural waters are monitored for their potential harmful effects. Tests for market authorisation and environmental monitoring usually involve the use of large numbers of organisms and, for ethical, cost and logistic reasons, there is a drive to develop alternative methods that can predict toxicity to fish without the need to expose any animals. There is therefore a great interest in the potential to use cultured fish cells in chemical toxicity testing. This review summarises the advances made in the area and focuses in particular on a system of cultured fish gill cells grown into an epithelium that permits direct treatment with water samples.

AB - A vast number of chemicals require environmental safety assessments for market authorisation. To ensure acceptable water quality, effluents and natural waters are monitored for their potential harmful effects. Tests for market authorisation and environmental monitoring usually involve the use of large numbers of organisms and, for ethical, cost and logistic reasons, there is a drive to develop alternative methods that can predict toxicity to fish without the need to expose any animals. There is therefore a great interest in the potential to use cultured fish cells in chemical toxicity testing. This review summarises the advances made in the area and focuses in particular on a system of cultured fish gill cells grown into an epithelium that permits direct treatment with water samples.

KW - FIGCS

KW - Biomonitoring

KW - Environmental risk assessment

KW - Fish

KW - In vitro

KW - Toxicology

KW - WATER RAINBOW-TROUT

KW - MITOCHONDRIA-RICH CELLS

KW - O-DEETHYLASE INDUCTION

KW - BLUEGILL BF-2 CELLS

KW - IN-VITRO METHOD

KW - FRESH-WATER

KW - ONCORHYNCHUS-MYKISS

KW - EPITHELIAL-CELLS

KW - FISH GILL

KW - INVITRO CYTOTOXICITY

U2 - 10.1242/jeb.095430

DO - 10.1242/jeb.095430

M3 - Literature review

SN - 0022-0949

VL - 217

SP - 639

EP - 650

JO - Journal of Experimental Biology

JF - Journal of Experimental Biology

IS - 5

ER -

Gill cell culture systems as models for aquatic environmental monitoring

Abstract

Keywords

UN SDGs

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