Glimpse into Hox and tale regulation of cell differentiation and reprogramming

Nuria Cerdá-Esteban, Francesca M. Spagnoli

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)

Abstract

During embryonic development, cells become gradually restricted in their developmental potential and start elaborating lineage‐specific transcriptional networks to ultimately acquire a unique differentiated state. Hox genes play a central role in specifying regional identities, thereby providing the cell with critical information on positional value along its differentiation path. The exquisite DNA‐binding specificity of the Hox proteins is frequently dependent upon their interaction with members of the TALE family of homeodomain proteins. In addition to their function as Hox‐cofactors, TALE homeoproteins control multiple crucial developmental processes through Hox‐independent mechanisms. Here, we will review recent findings on the function of both Hox and TALE proteins in cell differentiation, referring mostly to vertebrate species. In addition, we will discuss the direct implications of this knowledge on cell plasticity and cell reprogramming. Developmental Dynamics 243:76–87, 2014. © 2013 Wiley Periodicals, Inc.
Original languageEnglish
Pages (from-to)76-87
Number of pages12
JournalDevelopmental Dynamics
Volume243
Issue number1
Early online date12 Oct 2013
DOIs
Publication statusPublished - Jan 2014

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