Global daily dynamics of the pineal transcriptome

Diego M. Bustos, Michael J. Bailey, David Sugden, David A. Carter, Martin F. Rath, Morten Moller, Steven L. Coon, Joan L. Weller, David C. Klein

Research output: Contribution to journalLiterature reviewpeer-review

15 Citations (Scopus)

Abstract

Transcriptome profiling of the pineal gland has revealed night/day differences in the expression of a major fraction of the genes active in this tissue, with two-thirds of these being nocturnal increases. A set of over 600 transcripts exhibit two-fold to > 100-fold daily differences in abundance. These changes appear to be primarily attributable to adrenergic-cyclic-AMP-dependent mechanisms, which are controlled via a neural pathway that includes the suprachiasmatic nucleus, the master circadian oscillator. In addition to melatonin synthesis, night/day differences in gene expression impact genes associated with several specialized functions, including the immune/inflammation response, photo-transduction, and thyroid hormone/retinoic acid biology. The following nonspecialized cellular features are also affected: adhesion, cell cycle/cell death, cytoskeleton, DNA modification, endothelium, growth, RNA modification, small molecule biology, transcription factors, vesicle biology, signaling involving Ca2+, cyclic nucleotides, phospholipids, mitogen-activated protein kinases, the Wnt signaling pathway, and protein phosphorylation.
Original languageEnglish
Pages (from-to)1 - 11
Number of pages11
JournalCell and Tissue Research
Volume344
Issue number1
DOIs
Publication statusPublished - Apr 2011

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