@article{f2c48067373b440383939517867eb5c2,
title = "Global Guidelines in Dermatology Mapping Project (GUIDEMAP): a scoping review of dermatology clinical practice guidelines",
abstract = "Background: Clinical practice guidelines (CPGs) play a critical role in standardizing and improving treatment outcomes based on the available evidence. It is unclear how many CPGs are available globally to assist clinicians in the management of patients with skin disease. Objectives: To search for and identify CPGs for dermatological conditions with the highest burden globally. Methods: We adapted a list of 12 dermatological conditions with the highest burden from the Global Burden of Disease (GBD) study 2019. A systematic literature search was done to identify CPGs published between October 2014 to October 2019. The scoping review was conducted and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework. Results: A total of 226 CPGs were included. Melanoma had the greatest representation in the CPGs, followed by dermatitis and psoriasis. Skin cancers had a relatively high CPG representation but with lower GBD disease burden ranking. There was an uneven distribution by geographical region, with resource-poor settings being under-represented. The skin disease categories of the CPGs correlated weakly with the GBD disability-adjusted life-years metrics. Eighty-nine CPGs did not have funding disclosures and 34 CPGs were behind a paywall. Conclusions: The global production of dermatology CPGs showed wide variation in geographical representation, article accessibility and reporting of funding. The number of skin disease CPGs were not commensurate with its disease burden. Future work will critically appraise the methodology and quality of dermatology CPGs and lead to the production of an accessible online resource summarizing these findings.",
author = "Haw, {W. Y.} and A. Al-Janabi and Arents, {B. W.M.} and L. Asfour and Exton, {L. S.} and D. Grindlay and Khan, {S. S.} and L. Manounah and H. Yen and Chi, {C. C.} and {van Zuuren}, {E. J.} and C. Flohr and Yiu, {Z. Z.N.}",
note = "Funding Information: The concept of {\textquoteleft}disease burden{\textquoteright} can be expressed in terms of DALYs, calculated as the sum of years of life lost plus the years of productive life lost due to ill health, disability or premature death. The global burden of skin and subcutaneous diseases has been steadily increasing (total DALYs from 1·2% in 1990 to 1·8% in 2017). Our study showed weak association between DALYs and the representation of CPGs according to their skin disease categories. The findings are consistent with reports of poor association between global burden of disease and the number of published randomized trials, and moderate correlation between systematic reviews and DALYs across the entire Cochrane Database of Systematic Reviews. Furthermore, a study in 2015 comparing research funding by the US National Institutes of Health demonstrated that skin cancer research was generally overfunded, whereas dermatitis, decubitus ulcer, fungal skin diseases and cellulitis received substantially less financial support. Although skin cancers are represented by lower DALYs according to GBD metrics, their true burden is thought to be significantly underestimated, and thus might still be deemed important because of the associated morbidity and mortality. We recognize that many variables play a part in research prioritization and development of CPGs, including disease prevalence, therapeutic options, geographical and clinical settings, cost constraints and local resource availability, healthcare priority setting, pharmaceutical suppliers and public interest. 9,23 24 25 15 26,27 Publisher Copyright: {\textcopyright} 2021 The Authors. British Journal of Dermatology published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = oct,
doi = "10.1111/bjd.20428",
language = "English",
volume = "185",
pages = "736--744",
journal = "British Journal of Dermatology",
issn = "0007-0963",
publisher = "John Wiley & Sons, Ltd (10.1111)",
number = "4",
}
