Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents

Sylvane Desrivieres; Anbarasu Lourdusamy; Christian Mueller; Francesca Ducci; Cybele P. Wong; Marika Kaakinen; Anneli Pouta; Anna-Liisa Hartikainen; Matti Isohanni; Pimphen Charoen; Leena Peltonen; Nelson Freimer; Paul Elliott; Marjo-Riitta Jarvelin; Gunter Schumann

doi:10.1111/j.1369-1600.2010.00239.x

Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents

Sylvane Desrivieres, Anbarasu Lourdusamy, Christian Mueller, Francesca Ducci, Cybele P. Wong, Marika Kaakinen, Anneli Pouta, Anna-Liisa Hartikainen, Matti Isohanni, Pimphen Charoen, Leena Peltonen, Nelson Freimer, Paul Elliott, Marjo-Riitta Jarvelin, Gunter Schumann

Research output: Contribution to journal › Article › peer-review

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Abstract

Onset of alcohol use at an early age increases the risk for later alcohol dependence. We investigated the role of the glucocorticoid receptor (GR) gene (NR3C1) in onset of alcohol use and abuse in 14-year-old adolescents (n = 4534). Several NR3C1 polymorphisms were associated with onset of alcohol drinking or drunkenness at this age. Strongest associations were observed in females, with one marker (rs244465) remaining significant after correction for multiple testing (P-adj = 0.0067; odds ratio = 1.7, for drunkenness). Our data provide the first evidence that GR modulates initiation of alcohol abuse and reveal a polymorphism that might contribute to susceptibility to addiction.

Original language	English
Pages (from-to)	510 - 513
Number of pages	4
Journal	Addiction Biology
Volume	16
Issue number	3
DOIs	https://doi.org/10.1111/j.1369-1600.2010.00239.x
Publication status	Published - 2011

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Desrivieres, S., Lourdusamy, A., Mueller, C., Ducci, F., Wong, C. P., Kaakinen, M., Pouta, A., Hartikainen, A.-L., Isohanni, M., Charoen, P., Peltonen, L., Freimer, N., Elliott, P., Jarvelin, M.-R., & Schumann, G. (2011). Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents. Addiction Biology, 16(3), 510 - 513. https://doi.org/10.1111/j.1369-1600.2010.00239.x

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title = "Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents",

abstract = "Onset of alcohol use at an early age increases the risk for later alcohol dependence. We investigated the role of the glucocorticoid receptor (GR) gene (NR3C1) in onset of alcohol use and abuse in 14-year-old adolescents (n = 4534). Several NR3C1 polymorphisms were associated with onset of alcohol drinking or drunkenness at this age. Strongest associations were observed in females, with one marker (rs244465) remaining significant after correction for multiple testing (P-adj = 0.0067; odds ratio = 1.7, for drunkenness). Our data provide the first evidence that GR modulates initiation of alcohol abuse and reveal a polymorphism that might contribute to susceptibility to addiction.",

author = "Sylvane Desrivieres and Anbarasu Lourdusamy and Christian Mueller and Francesca Ducci and Wong, {Cybele P.} and Marika Kaakinen and Anneli Pouta and Anna-Liisa Hartikainen and Matti Isohanni and Pimphen Charoen and Leena Peltonen and Nelson Freimer and Paul Elliott and Marjo-Riitta Jarvelin and Gunter Schumann",

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doi = "10.1111/j.1369-1600.2010.00239.x",

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Desrivieres, S , Lourdusamy, A, Mueller, C, Ducci, F , Wong, CP, Kaakinen, M, Pouta, A, Hartikainen, A-L, Isohanni, M, Charoen, P, Peltonen, L, Freimer, N, Elliott, P, Jarvelin, M-R & Schumann, G 2011, 'Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents', Addiction Biology, vol. 16, no. 3, pp. 510 - 513. https://doi.org/10.1111/j.1369-1600.2010.00239.x

TY - JOUR

T1 - Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents

AU - Desrivieres, Sylvane

AU - Lourdusamy, Anbarasu

AU - Mueller, Christian

AU - Ducci, Francesca

AU - Wong, Cybele P.

AU - Kaakinen, Marika

AU - Pouta, Anneli

AU - Hartikainen, Anna-Liisa

AU - Isohanni, Matti

AU - Charoen, Pimphen

AU - Peltonen, Leena

AU - Freimer, Nelson

AU - Elliott, Paul

AU - Jarvelin, Marjo-Riitta

AU - Schumann, Gunter

PY - 2011

Y1 - 2011

N2 - Onset of alcohol use at an early age increases the risk for later alcohol dependence. We investigated the role of the glucocorticoid receptor (GR) gene (NR3C1) in onset of alcohol use and abuse in 14-year-old adolescents (n = 4534). Several NR3C1 polymorphisms were associated with onset of alcohol drinking or drunkenness at this age. Strongest associations were observed in females, with one marker (rs244465) remaining significant after correction for multiple testing (P-adj = 0.0067; odds ratio = 1.7, for drunkenness). Our data provide the first evidence that GR modulates initiation of alcohol abuse and reveal a polymorphism that might contribute to susceptibility to addiction.

AB - Onset of alcohol use at an early age increases the risk for later alcohol dependence. We investigated the role of the glucocorticoid receptor (GR) gene (NR3C1) in onset of alcohol use and abuse in 14-year-old adolescents (n = 4534). Several NR3C1 polymorphisms were associated with onset of alcohol drinking or drunkenness at this age. Strongest associations were observed in females, with one marker (rs244465) remaining significant after correction for multiple testing (P-adj = 0.0067; odds ratio = 1.7, for drunkenness). Our data provide the first evidence that GR modulates initiation of alcohol abuse and reveal a polymorphism that might contribute to susceptibility to addiction.

U2 - 10.1111/j.1369-1600.2010.00239.x

DO - 10.1111/j.1369-1600.2010.00239.x

M3 - Article

VL - 16

SP - 510

EP - 513

JO - Addiction Biology

JF - Addiction Biology

IS - 3

ER -

Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents

Abstract

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