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Glutamate and functional connectivity-Support for the excitatory-inhibitory imbalance hypothesis in autism spectrum disorders

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Glutamate and functional connectivity-Support for the excitatory-inhibitory imbalance hypothesis in autism spectrum disorders. / Siegel-Ramsay, Jennifer; Romaniuk, Liana; Whalley, Heather; Roberts, Neil; Branigan, Holly; Stanfield, Andrew; Lawrie, Stephen; Dauvermann, Maria.

In: Psychiatry Research. Neuroimaging, Vol. 313, 111302, 30.07.2021.

Research output: Contribution to journalArticlepeer-review

Harvard

Siegel-Ramsay, J, Romaniuk, L, Whalley, H, Roberts, N, Branigan, H, Stanfield, A, Lawrie, S & Dauvermann, M 2021, 'Glutamate and functional connectivity-Support for the excitatory-inhibitory imbalance hypothesis in autism spectrum disorders', Psychiatry Research. Neuroimaging, vol. 313, 111302. https://doi.org/10.1016/j.pscychresns.2021.111302

APA

Siegel-Ramsay, J., Romaniuk, L., Whalley, H., Roberts, N., Branigan, H., Stanfield, A., Lawrie, S., & Dauvermann, M. (2021). Glutamate and functional connectivity-Support for the excitatory-inhibitory imbalance hypothesis in autism spectrum disorders. Psychiatry Research. Neuroimaging, 313, [111302]. https://doi.org/10.1016/j.pscychresns.2021.111302

Vancouver

Siegel-Ramsay J, Romaniuk L, Whalley H, Roberts N, Branigan H, Stanfield A et al. Glutamate and functional connectivity-Support for the excitatory-inhibitory imbalance hypothesis in autism spectrum disorders. Psychiatry Research. Neuroimaging. 2021 Jul 30;313. 111302. https://doi.org/10.1016/j.pscychresns.2021.111302

Author

Siegel-Ramsay, Jennifer ; Romaniuk, Liana ; Whalley, Heather ; Roberts, Neil ; Branigan, Holly ; Stanfield, Andrew ; Lawrie, Stephen ; Dauvermann, Maria. / Glutamate and functional connectivity-Support for the excitatory-inhibitory imbalance hypothesis in autism spectrum disorders. In: Psychiatry Research. Neuroimaging. 2021 ; Vol. 313.

Bibtex Download

@article{5b488e0affeb41e68b1bd5dd26c40e3e,
title = "Glutamate and functional connectivity-Support for the excitatory-inhibitory imbalance hypothesis in autism spectrum disorders",
abstract = "It has been proposed that the Glutamate (Glu) system is implicated in autism spectrum disorders (ASD) via an imbalance between excitatory and inhibitory brain circuits, which impacts on brain function. Here, we investigated the excitatory-inhibitory imbalance theory by measuring Glu-concentrations and the relationship with resting-state function. Nineteen adult males with ASD and 19 age and sex-matched healthy controls (HC) (23 - 58 years) underwent Proton Magnetic Resonance Spectroscopy of the dorsal anterior cingulate cortex (dACC) and resting-state functional Magnetic Resonance Imaging (fMRI). Glu and Glx concentrations were compared between groups. Seed-based functional connectivity was analyzed with a priori seeds of the right and left dACC. Finally, metabolite concentrations were related to functional connectivity coefficients and compared between both groups. Individuals with ASD showed significantly negative associations between increased Glx concentrations and reduced functional connectivity between the dACC and insular, limbic and parietal regions. In contrast, HC displayed a positive relationship between the same metabolite and connectivity measures. We provided new evidence to support the excitatory-inhibitory imbalance theory, where excitatory Glx concentrations were related to functional dysconnectivity in ASD. Future research is needed to investigate large-scale functional networks in association with both excitatory and inhibitory metabolites in subpopulations of ASD.",
author = "Jennifer Siegel-Ramsay and Liana Romaniuk and Heather Whalley and Neil Roberts and Holly Branigan and Andrew Stanfield and Stephen Lawrie and Maria Dauvermann",
note = "Funding Information: We sincerely thank all participants who took part in the study. The scans were acquired at the Edinburgh Imaging Facility in the Queen's Medical Research Institute (EIF-QMRI). We would like to thank Dr. Scott Semple (MRI physicist), Annette Cooper, and her team of radiographers at EIF-QMRI for help in organizing the study and acquiring the scans. The investigators also acknowledge the support of the Scottish Mental Health Research Network (www.smhrn.org.uk), particularly Dr. James McKirdy, who assisted with subject recruitment. Funding Information: This work was funded by a research grant to MRD, ASC and SML from the RS MacDonald Charitable Trust, Edinburgh [2011]. The Patrick Wild center contributed to PhD costs for JES. These funding sources have no involvement in the article preparation Publisher Copyright: {\textcopyright} 2021 The Author(s) Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = jul,
day = "30",
doi = "10.1016/j.pscychresns.2021.111302",
language = "English",
volume = "313",
journal = "Psychiatry Research. Neuroimaging",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Glutamate and functional connectivity-Support for the excitatory-inhibitory imbalance hypothesis in autism spectrum disorders

AU - Siegel-Ramsay, Jennifer

AU - Romaniuk, Liana

AU - Whalley, Heather

AU - Roberts, Neil

AU - Branigan, Holly

AU - Stanfield, Andrew

AU - Lawrie, Stephen

AU - Dauvermann, Maria

N1 - Funding Information: We sincerely thank all participants who took part in the study. The scans were acquired at the Edinburgh Imaging Facility in the Queen's Medical Research Institute (EIF-QMRI). We would like to thank Dr. Scott Semple (MRI physicist), Annette Cooper, and her team of radiographers at EIF-QMRI for help in organizing the study and acquiring the scans. The investigators also acknowledge the support of the Scottish Mental Health Research Network (www.smhrn.org.uk), particularly Dr. James McKirdy, who assisted with subject recruitment. Funding Information: This work was funded by a research grant to MRD, ASC and SML from the RS MacDonald Charitable Trust, Edinburgh [2011]. The Patrick Wild center contributed to PhD costs for JES. These funding sources have no involvement in the article preparation Publisher Copyright: © 2021 The Author(s) Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/7/30

Y1 - 2021/7/30

N2 - It has been proposed that the Glutamate (Glu) system is implicated in autism spectrum disorders (ASD) via an imbalance between excitatory and inhibitory brain circuits, which impacts on brain function. Here, we investigated the excitatory-inhibitory imbalance theory by measuring Glu-concentrations and the relationship with resting-state function. Nineteen adult males with ASD and 19 age and sex-matched healthy controls (HC) (23 - 58 years) underwent Proton Magnetic Resonance Spectroscopy of the dorsal anterior cingulate cortex (dACC) and resting-state functional Magnetic Resonance Imaging (fMRI). Glu and Glx concentrations were compared between groups. Seed-based functional connectivity was analyzed with a priori seeds of the right and left dACC. Finally, metabolite concentrations were related to functional connectivity coefficients and compared between both groups. Individuals with ASD showed significantly negative associations between increased Glx concentrations and reduced functional connectivity between the dACC and insular, limbic and parietal regions. In contrast, HC displayed a positive relationship between the same metabolite and connectivity measures. We provided new evidence to support the excitatory-inhibitory imbalance theory, where excitatory Glx concentrations were related to functional dysconnectivity in ASD. Future research is needed to investigate large-scale functional networks in association with both excitatory and inhibitory metabolites in subpopulations of ASD.

AB - It has been proposed that the Glutamate (Glu) system is implicated in autism spectrum disorders (ASD) via an imbalance between excitatory and inhibitory brain circuits, which impacts on brain function. Here, we investigated the excitatory-inhibitory imbalance theory by measuring Glu-concentrations and the relationship with resting-state function. Nineteen adult males with ASD and 19 age and sex-matched healthy controls (HC) (23 - 58 years) underwent Proton Magnetic Resonance Spectroscopy of the dorsal anterior cingulate cortex (dACC) and resting-state functional Magnetic Resonance Imaging (fMRI). Glu and Glx concentrations were compared between groups. Seed-based functional connectivity was analyzed with a priori seeds of the right and left dACC. Finally, metabolite concentrations were related to functional connectivity coefficients and compared between both groups. Individuals with ASD showed significantly negative associations between increased Glx concentrations and reduced functional connectivity between the dACC and insular, limbic and parietal regions. In contrast, HC displayed a positive relationship between the same metabolite and connectivity measures. We provided new evidence to support the excitatory-inhibitory imbalance theory, where excitatory Glx concentrations were related to functional dysconnectivity in ASD. Future research is needed to investigate large-scale functional networks in association with both excitatory and inhibitory metabolites in subpopulations of ASD.

UR - http://www.scopus.com/inward/record.url?scp=85106953675&partnerID=8YFLogxK

U2 - 10.1016/j.pscychresns.2021.111302

DO - 10.1016/j.pscychresns.2021.111302

M3 - Article

VL - 313

JO - Psychiatry Research. Neuroimaging

JF - Psychiatry Research. Neuroimaging

M1 - 111302

ER -

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