GLUTEN-FREE DIET DOES NOT INFLUENCE THE OCCURRENCE AND THE TH1/TH17-TH2 NATURE OF IMMUNE-MEDIATED DISEASES IN PATIENTS WITH COELIAC DISEASE

TY - JOUR

T1 - GLUTEN-FREE DIET DOES NOT INFLUENCE THE OCCURRENCE AND THE TH1/TH17-TH2 NATURE OF IMMUNE-MEDIATED DISEASES IN PATIENTS WITH COELIAC DISEASE

AU - Imperatore, N.

AU - Rispo, A.

AU - Capone, P.

AU - Donetto, S.

AU - De Palma, G.D.

AU - Gerbino, N.

AU - Rea, M.

AU - Caporaso, N.

AU - Tortora, R.

PY - 2016/4/9

Y1 - 2016/4/9

N2 - SUMMARYIntroduction Coeliac disease (CD) is the most common Th1-mediated enteropathy, frequently associated with other immune-mediated disorders (IMD). Aims: to evaluate: 1) the prevalence of IMD at the time of and after CD diagnosis; 2) a possible change in immune response to gluten free diet (GFD); 3) the potential role of GFD in reducing and/or preventing IMD in CD. Methods: prospective study including all consecutive adult CD patients who underwent investigations for Th1-Th17/Th2-IMD at the time of CD diagnosis and after a 5-year follow-up period. Results: 1255 CD were enrolled. Of these, 257 patients (20.5%) showed IMD at the time of CD diagnosis, with 58.4% presenting a Th1/Th17-IMD. After a 5-year follow-up period, 682 patients (54.3%) showed new IMD despite GFD. Of these, 57.3% presented a Th1/Th17-IMD and 42.7% a Th2-IMD (p = 0.8). When compared the prevalence of each type of IMD before and after CD diagnosis, we did not identify any significant “switch” from Th1/Th17- to Th2-IMD or vice versa. The number of patients with Th1/Th17- and/or Th2-IMD increased during the GFD period (20.5% vs 54.3%; p < 0.01; OR 1.9). Conclusions: The prevalence of IMD at the time of CD diagnosis is high and it seems to increase in the follow-up period despite GFD.

AB - SUMMARYIntroduction Coeliac disease (CD) is the most common Th1-mediated enteropathy, frequently associated with other immune-mediated disorders (IMD). Aims: to evaluate: 1) the prevalence of IMD at the time of and after CD diagnosis; 2) a possible change in immune response to gluten free diet (GFD); 3) the potential role of GFD in reducing and/or preventing IMD in CD. Methods: prospective study including all consecutive adult CD patients who underwent investigations for Th1-Th17/Th2-IMD at the time of CD diagnosis and after a 5-year follow-up period. Results: 1255 CD were enrolled. Of these, 257 patients (20.5%) showed IMD at the time of CD diagnosis, with 58.4% presenting a Th1/Th17-IMD. After a 5-year follow-up period, 682 patients (54.3%) showed new IMD despite GFD. Of these, 57.3% presented a Th1/Th17-IMD and 42.7% a Th2-IMD (p = 0.8). When compared the prevalence of each type of IMD before and after CD diagnosis, we did not identify any significant “switch” from Th1/Th17- to Th2-IMD or vice versa. The number of patients with Th1/Th17- and/or Th2-IMD increased during the GFD period (20.5% vs 54.3%; p < 0.01; OR 1.9). Conclusions: The prevalence of IMD at the time of CD diagnosis is high and it seems to increase in the follow-up period despite GFD.

KW - Coeliac disease

KW - gluten

KW - autoimmunity

KW - immuno-mediated diseases

KW - Th1

KW - Th2

KW - Th17

U2 - 10.1016/j.dld.2016.03.026

DO - 10.1016/j.dld.2016.03.026

M3 - Article

SN - 1590-8658

JO - DIGESTIVE AND LIVER DISEASE

JF - DIGESTIVE AND LIVER DISEASE

ER -