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GLUTEN-FREE DIET DOES NOT INFLUENCE THE OCCURRENCE AND THE TH1/TH17-TH2 NATURE OF IMMUNE-MEDIATED DISEASES IN PATIENTS WITH COELIAC DISEASE

Research output: Contribution to journalArticle

N. Imperatore, A. Rispo, P. Capone, S. Donetto, G.D. De Palma, N. Gerbino, M. Rea, N. Caporaso, R. Tortora

Original languageEnglish
JournalDIGESTIVE AND LIVER DISEASE
Early online date9 Apr 2016
DOIs
Publication statusE-pub ahead of print - 9 Apr 2016

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Abstract

SUMMARYIntroduction Coeliac disease (CD) is the most common Th1-mediated enteropathy, frequently associated with other immune-mediated disorders (IMD). Aims: to evaluate: 1) the prevalence of IMD at the time of and after CD diagnosis; 2) a possible change in immune response to gluten free diet (GFD); 3) the potential role of GFD in reducing and/or preventing IMD in CD. Methods: prospective study including all consecutive adult CD patients who underwent investigations for Th1-Th17/Th2-IMD at the time of CD diagnosis and after a 5-year follow-up period. Results: 1255 CD were enrolled. Of these, 257 patients (20.5%) showed IMD at the time of CD diagnosis, with 58.4% presenting a Th1/Th17-IMD. After a 5-year follow-up period, 682 patients (54.3%) showed new IMD despite GFD. Of these, 57.3% presented a Th1/Th17-IMD and 42.7% a Th2-IMD (p = 0.8). When compared the prevalence of each type of IMD before and after CD diagnosis, we did not identify any significant “switch” from Th1/Th17- to Th2-IMD or vice versa. The number of patients with Th1/Th17- and/or Th2-IMD increased during the GFD period (20.5% vs 54.3%; p < 0.01; OR 1.9). Conclusions: The prevalence of IMD at the time of CD diagnosis is high and it seems to increase in the follow-up period despite GFD.

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