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GLUTEN-FREE DIET DOES NOT INFLUENCE THE OCCURRENCE AND THE TH1/TH17-TH2 NATURE OF IMMUNE-MEDIATED DISEASES IN PATIENTS WITH COELIAC DISEASE

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GLUTEN-FREE DIET DOES NOT INFLUENCE THE OCCURRENCE AND THE TH1/TH17-TH2 NATURE OF IMMUNE-MEDIATED DISEASES IN PATIENTS WITH COELIAC DISEASE. / Imperatore, N.; Rispo, A.; Capone, P.; Donetto, S.; De Palma, G.D.; Gerbino, N.; Rea, M.; Caporaso, N.; Tortora, R.

In: DIGESTIVE AND LIVER DISEASE, 09.04.2016.

Research output: Contribution to journalArticlepeer-review

Harvard

Imperatore, N, Rispo, A, Capone, P, Donetto, S, De Palma, GD, Gerbino, N, Rea, M, Caporaso, N & Tortora, R 2016, 'GLUTEN-FREE DIET DOES NOT INFLUENCE THE OCCURRENCE AND THE TH1/TH17-TH2 NATURE OF IMMUNE-MEDIATED DISEASES IN PATIENTS WITH COELIAC DISEASE', DIGESTIVE AND LIVER DISEASE. https://doi.org/10.1016/j.dld.2016.03.026

APA

Imperatore, N., Rispo, A., Capone, P., Donetto, S., De Palma, G. D., Gerbino, N., Rea, M., Caporaso, N., & Tortora, R. (2016). GLUTEN-FREE DIET DOES NOT INFLUENCE THE OCCURRENCE AND THE TH1/TH17-TH2 NATURE OF IMMUNE-MEDIATED DISEASES IN PATIENTS WITH COELIAC DISEASE. DIGESTIVE AND LIVER DISEASE. https://doi.org/10.1016/j.dld.2016.03.026

Vancouver

Imperatore N, Rispo A, Capone P, Donetto S, De Palma GD, Gerbino N et al. GLUTEN-FREE DIET DOES NOT INFLUENCE THE OCCURRENCE AND THE TH1/TH17-TH2 NATURE OF IMMUNE-MEDIATED DISEASES IN PATIENTS WITH COELIAC DISEASE. DIGESTIVE AND LIVER DISEASE. 2016 Apr 9. https://doi.org/10.1016/j.dld.2016.03.026

Author

Imperatore, N. ; Rispo, A. ; Capone, P. ; Donetto, S. ; De Palma, G.D. ; Gerbino, N. ; Rea, M. ; Caporaso, N. ; Tortora, R. / GLUTEN-FREE DIET DOES NOT INFLUENCE THE OCCURRENCE AND THE TH1/TH17-TH2 NATURE OF IMMUNE-MEDIATED DISEASES IN PATIENTS WITH COELIAC DISEASE. In: DIGESTIVE AND LIVER DISEASE. 2016.

Bibtex Download

@article{9e629690328b4578bc3b5672410cf5a7,
title = "GLUTEN-FREE DIET DOES NOT INFLUENCE THE OCCURRENCE AND THE TH1/TH17-TH2 NATURE OF IMMUNE-MEDIATED DISEASES IN PATIENTS WITH COELIAC DISEASE",
abstract = "SUMMARYIntroduction Coeliac disease (CD) is the most common Th1-mediated enteropathy, frequently associated with other immune-mediated disorders (IMD). Aims: to evaluate: 1) the prevalence of IMD at the time of and after CD diagnosis; 2) a possible change in immune response to gluten free diet (GFD); 3) the potential role of GFD in reducing and/or preventing IMD in CD. Methods: prospective study including all consecutive adult CD patients who underwent investigations for Th1-Th17/Th2-IMD at the time of CD diagnosis and after a 5-year follow-up period. Results: 1255 CD were enrolled. Of these, 257 patients (20.5%) showed IMD at the time of CD diagnosis, with 58.4% presenting a Th1/Th17-IMD. After a 5-year follow-up period, 682 patients (54.3%) showed new IMD despite GFD. Of these, 57.3% presented a Th1/Th17-IMD and 42.7% a Th2-IMD (p = 0.8). When compared the prevalence of each type of IMD before and after CD diagnosis, we did not identify any significant “switch” from Th1/Th17- to Th2-IMD or vice versa. The number of patients with Th1/Th17- and/or Th2-IMD increased during the GFD period (20.5% vs 54.3%; p < 0.01; OR 1.9). Conclusions: The prevalence of IMD at the time of CD diagnosis is high and it seems to increase in the follow-up period despite GFD.",
keywords = "Coeliac disease, gluten, autoimmunity, immuno-mediated diseases, Th1, Th2, Th17",
author = "N. Imperatore and A. Rispo and P. Capone and S. Donetto and {De Palma}, G.D. and N. Gerbino and M. Rea and N. Caporaso and R. Tortora",
year = "2016",
month = apr,
day = "9",
doi = "10.1016/j.dld.2016.03.026",
language = "English",
journal = "DIGESTIVE AND LIVER DISEASE",
issn = "1590-8658",
publisher = "Elsevier",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - GLUTEN-FREE DIET DOES NOT INFLUENCE THE OCCURRENCE AND THE TH1/TH17-TH2 NATURE OF IMMUNE-MEDIATED DISEASES IN PATIENTS WITH COELIAC DISEASE

AU - Imperatore, N.

AU - Rispo, A.

AU - Capone, P.

AU - Donetto, S.

AU - De Palma, G.D.

AU - Gerbino, N.

AU - Rea, M.

AU - Caporaso, N.

AU - Tortora, R.

PY - 2016/4/9

Y1 - 2016/4/9

N2 - SUMMARYIntroduction Coeliac disease (CD) is the most common Th1-mediated enteropathy, frequently associated with other immune-mediated disorders (IMD). Aims: to evaluate: 1) the prevalence of IMD at the time of and after CD diagnosis; 2) a possible change in immune response to gluten free diet (GFD); 3) the potential role of GFD in reducing and/or preventing IMD in CD. Methods: prospective study including all consecutive adult CD patients who underwent investigations for Th1-Th17/Th2-IMD at the time of CD diagnosis and after a 5-year follow-up period. Results: 1255 CD were enrolled. Of these, 257 patients (20.5%) showed IMD at the time of CD diagnosis, with 58.4% presenting a Th1/Th17-IMD. After a 5-year follow-up period, 682 patients (54.3%) showed new IMD despite GFD. Of these, 57.3% presented a Th1/Th17-IMD and 42.7% a Th2-IMD (p = 0.8). When compared the prevalence of each type of IMD before and after CD diagnosis, we did not identify any significant “switch” from Th1/Th17- to Th2-IMD or vice versa. The number of patients with Th1/Th17- and/or Th2-IMD increased during the GFD period (20.5% vs 54.3%; p < 0.01; OR 1.9). Conclusions: The prevalence of IMD at the time of CD diagnosis is high and it seems to increase in the follow-up period despite GFD.

AB - SUMMARYIntroduction Coeliac disease (CD) is the most common Th1-mediated enteropathy, frequently associated with other immune-mediated disorders (IMD). Aims: to evaluate: 1) the prevalence of IMD at the time of and after CD diagnosis; 2) a possible change in immune response to gluten free diet (GFD); 3) the potential role of GFD in reducing and/or preventing IMD in CD. Methods: prospective study including all consecutive adult CD patients who underwent investigations for Th1-Th17/Th2-IMD at the time of CD diagnosis and after a 5-year follow-up period. Results: 1255 CD were enrolled. Of these, 257 patients (20.5%) showed IMD at the time of CD diagnosis, with 58.4% presenting a Th1/Th17-IMD. After a 5-year follow-up period, 682 patients (54.3%) showed new IMD despite GFD. Of these, 57.3% presented a Th1/Th17-IMD and 42.7% a Th2-IMD (p = 0.8). When compared the prevalence of each type of IMD before and after CD diagnosis, we did not identify any significant “switch” from Th1/Th17- to Th2-IMD or vice versa. The number of patients with Th1/Th17- and/or Th2-IMD increased during the GFD period (20.5% vs 54.3%; p < 0.01; OR 1.9). Conclusions: The prevalence of IMD at the time of CD diagnosis is high and it seems to increase in the follow-up period despite GFD.

KW - Coeliac disease

KW - gluten

KW - autoimmunity

KW - immuno-mediated diseases

KW - Th1

KW - Th2

KW - Th17

U2 - 10.1016/j.dld.2016.03.026

DO - 10.1016/j.dld.2016.03.026

M3 - Article

JO - DIGESTIVE AND LIVER DISEASE

JF - DIGESTIVE AND LIVER DISEASE

SN - 1590-8658

ER -

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