Glycogen synthase kinase-3 beta immunoreactivity is reduced in the prefrontal cortex in schizophrenia

C Beasley, D Cotter, N Khan, C Pollard, P Sheppard, I Varndell, S Lovestone, B Anderton, I Everall

Research output: Contribution to journalArticlepeer-review

110 Citations (Scopus)

Abstract

Cytoarchitectural abnormalities have been reported in the cortex in schizophrenia. These suggest a developmental origin for this disorder. The Wnt signalling pathway is involved in the regulation of brain development; disruption of this pathway may lead to abnormal cortical development. In this study levels of three components of the Wnt signalling pathway; glycogen synthase kinase-3 beta (GSK-3 beta), beta -catenin and dishevelled-2 (Dvl-2) were determined in the prefrontal cortex of ten schizophrenic and ten control individuals using immunoblotting. GSK-3 beta levels were significantly reduced in the schizophrenic group, while levels of beta -catenin and Dvl-2 did not differ between groups. This provides further evidence for an abnormality of the Wnt signalling pathway in schizophrenia. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)117 - 120
Number of pages4
JournalNeuroscience Letters
Volume302
Issue number2-3
DOIs
Publication statusPublished - 20 Apr 2001

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