Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT)

Linda Clare*, Antony Bayer, Alistair Burns, Anne Corbett, Roy Jones, Martin Knapp, M.D. Kopelman, Aleksandra Kudlicka, Iracema Leroi, Jan Oyebode, Jackie Pool, Bob Woods, Rhiannon Whitaker

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

72 Citations (Scopus)

Abstract

Background: Preliminary evidence suggests that goal-oriented cognitive rehabilitation (CR) may be a clinically effective intervention for people with early-stage Alzheimer's disease, vascular or mixed dementia and their carers. This study aims to establish whether CR is a clinically effective and cost-effective intervention for people with early-stage dementia and their carers.

Methods/design: In this multi-centre, single-blind randomised controlled trial, 480 people with early-stage dementia, each with a carer, will be randomised to receive either treatment as usual or cognitive rehabilitation (10 therapy sessions over 3 months, followed by 4 maintenance sessions over 6 months). We will compare the effectiveness of cognitive rehabilitation with that of treatment as usual with regard to improving self-reported and carer-rated goal performance in areas identified as causing concern by people with early-stage dementia; improving quality of life, self-efficacy, mood and cognition of people with early-stage dementia; and reducing stress levels and ameliorating quality of life for carers of participants with early-stage dementia. The incremental cost-effectiveness of goal-oriented cognitive rehabilitation compared to treatment as usual will also be examined.

Discussion: If the study confirms the benefits and cost-effectiveness of cognitive rehabilitation, it will be important to examine how the goal-oriented cognitive rehabilitation approach can most effectively be integrated into routine health-care provision. Our aim is to provide training and develop materials to support the implementation of this approach following trial completion.

Original languageEnglish
Article number152
Pages (from-to)N/A
Number of pages15
JournalTrials
Volume14
Issue numberN/A
DOIs
Publication statusPublished - 27 May 2013

Keywords

  • Alzheimer's disease
  • Vascular dementia
  • Mixed dementia
  • Re-ablement
  • Quality of life
  • Cost-effectiveness
  • OCCUPATIONAL PERFORMANCE-MEASURE
  • FACE-NAME ASSOCIATIONS
  • EARLY ALZHEIMERS-DISEASE
  • QUALITY-OF-LIFE
  • BRAIN-INJURY
  • PEOPLE
  • HEALTH
  • INTERVENTION
  • METAANALYSIS
  • AWARENESS

Fingerprint

Dive into the research topics of 'Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT)'. Together they form a unique fingerprint.

Cite this