Gold nanoparticle-mediated gene delivery induces widespread changes in the expression of innate immunity genes

E-Y Kim, R. Schulz, P. Swantek, K. Kunstman, M. H. Malim, S. M. Wolinsky

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)

Abstract

The unique properties of oligonucleotide (and small interfering RNA)-modified gold nanoparticle conjugates make them promising intracellular gene regulation agents. We found that gold nanoparticles stably functionalized with covalently attached oligonucleotides activate immune-related genes and pathways in human peripheral blood mononuclear cells, but not an immortalized, lineage-restricted cell line. These findings have strong implications for the application of oligonucleotide-modified gold nanoparticle conjugates in translational research and in the development of therapeutics and gene delivery systems. Gene Therapy (2012) 19, 347-353; doi:10.1038/gt.2011.95; published online 23 June 2011
Original languageEnglish
Pages (from-to)347 - 353
Number of pages7
JournalGene Therapy
Volume19
Issue number3
DOIs
Publication statusPublished - Mar 2012

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