King's College London

Research portal

Golgipathies in Neurodevelopment: A New View of Old Defects

Research output: Contribution to journalReview article

Sowmyalakshmi Rasika, Sandrine Passemard, Alain Verloes, Pierre Gressens, Vincent El Ghouzzi

Original languageEnglish
Pages (from-to)396-416
Number of pages21
JournalDevelopmental Neuroscience
Volume40
Issue number5-6
Early online date15 Mar 2019
DOIs
Publication statusPublished - 1 Jul 2019

Bibliographical note

© 2019 S. Karger AG, Basel.

Documents

King's Authors

Abstract

The Golgi apparatus (GA) is involved in a whole spectrum of activities, from lipid biosynthesis and membrane secretion to the posttranslational processing and trafficking of most proteins, the control of mitosis, cell polarity, migration and morphogenesis, and diverse processes such as apoptosis, autophagy, and the stress response. In keeping with its versatility, mutations in GA proteins lead to a number of different disorders, including syndromes with multisystem involvement. Intriguingly, however, > 40% of the GA-related genes known to be associated with disease affect the central or peripheral nervous system, highlighting the critical importance of the GA for neural function. We have previously proposed the term "Golgipathies" in relation to a group of disorders in which mutations in GA proteins or their molecular partners lead to consequences for brain development, in particular postnatal-onset microcephaly (POM), white-matter defects, and intellectual disability (ID). Here, taking into account the broader role of the GA in the nervous system, we refine and enlarge this emerging concept to include other disorders whose symptoms may be indicative of altered neurodevelopmental processes, from neurogenesis to neuronal migration and the secretory function critical for the maturation of postmitotic neurons and myelination.

Download statistics

No data available

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454