Gradients of cortical hierarchy in Autism

Richard AI Bethlehem; Marcel Falkiewicz; Jan Freyberg; Owen E Parsons; Seyedeh-Rezvan Farahibozorg; Charlotte Pretzsch; Bjoern Soergel; Daniel S Margulies

doi:10.3897/rio.3.e13391

Gradients of cortical hierarchy in Autism

Richard AI Bethlehem, Marcel Falkiewicz, Jan Freyberg, Owen E Parsons, Seyedeh-Rezvan Farahibozorg, Charlotte Pretzsch, Bjoern Soergel, Daniel S Margulies

University of Cambridge

Research output: Contribution to journal › Article › peer-review

Abstract

Autism is a developmental condition associated with altered functional connectivity. We propose to re-frame the functional connectivity alterations in terms of gradients that capture the functional hierarchy of cortical processing from sensory to default-mode network regions. We hypothesized that this hierarchy will be altered in ASD. To test that, we compared the scale of gradients in people with autism and healthy controls. The present results do not support our hypothesis. There are two alternative implications: either the processing hierarchies are preserved in autism or the scale of the gradients does not capture them. In the future we will attempt to settle which alternative is more likely.

Original language	English
Article number	e13391
Journal	Research Ideas and Outcomes
DOIs	https://doi.org/10.3897/rio.3.e13391
Publication status	Published - 2 May 2017

Access to Document

10.3897/rio.3.e13391Licence: CC BY

Cite this

@article{8a9ac04b1544470bbfb1c652e91fe662,

title = "Gradients of cortical hierarchy in Autism",

abstract = "Autism is a developmental condition associated with altered functional connectivity. We propose to re-frame the functional connectivity alterations in terms of gradients that capture the functional hierarchy of cortical processing from sensory to default-mode network regions. We hypothesized that this hierarchy will be altered in ASD. To test that, we compared the scale of gradients in people with autism and healthy controls. The present results do not support our hypothesis. There are two alternative implications: either the processing hierarchies are preserved in autism or the scale of the gradients does not capture them. In the future we will attempt to settle which alternative is more likely.",

author = "Bethlehem, {Richard AI} and Marcel Falkiewicz and Jan Freyberg and Parsons, {Owen E} and Seyedeh-Rezvan Farahibozorg and Charlotte Pretzsch and Bjoern Soergel and Margulies, {Daniel S}",

year = "2017",

month = may,

day = "2",

doi = "10.3897/rio.3.e13391",

language = "English",

journal = "Research Ideas and Outcomes",

}

TY - JOUR

T1 - Gradients of cortical hierarchy in Autism

AU - Bethlehem, Richard AI

AU - Falkiewicz, Marcel

AU - Freyberg, Jan

AU - Parsons, Owen E

AU - Farahibozorg, Seyedeh-Rezvan

AU - Pretzsch, Charlotte

AU - Soergel, Bjoern

AU - Margulies, Daniel S

PY - 2017/5/2

Y1 - 2017/5/2

N2 - Autism is a developmental condition associated with altered functional connectivity. We propose to re-frame the functional connectivity alterations in terms of gradients that capture the functional hierarchy of cortical processing from sensory to default-mode network regions. We hypothesized that this hierarchy will be altered in ASD. To test that, we compared the scale of gradients in people with autism and healthy controls. The present results do not support our hypothesis. There are two alternative implications: either the processing hierarchies are preserved in autism or the scale of the gradients does not capture them. In the future we will attempt to settle which alternative is more likely.

AB - Autism is a developmental condition associated with altered functional connectivity. We propose to re-frame the functional connectivity alterations in terms of gradients that capture the functional hierarchy of cortical processing from sensory to default-mode network regions. We hypothesized that this hierarchy will be altered in ASD. To test that, we compared the scale of gradients in people with autism and healthy controls. The present results do not support our hypothesis. There are two alternative implications: either the processing hierarchies are preserved in autism or the scale of the gradients does not capture them. In the future we will attempt to settle which alternative is more likely.

U2 - 10.3897/rio.3.e13391

DO - 10.3897/rio.3.e13391

M3 - Article

JO - Research Ideas and Outcomes

JF - Research Ideas and Outcomes

M1 - e13391

ER -

Gradients of cortical hierarchy in Autism

Abstract

Access to Document

Fingerprint

Cite this