Granulocyte colony-stimulating factor improves function of neutrophils from patients with acute liver failure

N Rolando, M Clapperton, J Wade, G Panetsos, G Mufti, R Williams

    Research output: Contribution to journalArticlepeer-review

    40 Citations (Scopus)

    Abstract

    Objective To evaluate the in vitro effects of granulocyte colony-stimulating factor (G-CSF) on function of neutrophils in acute liver failure (ALF). Methods Neutrophil functions (superoxide and hydrogen peroxide production; phagocytosis and killing; complement receptor expression) were determined simultaneously in 23 patients with ALF due to paracetamol overdose and compared with 23 healthy control subjects. Results Phagocytosis was reduced in neutrophils from ALF patients compared to controls (P
    Original languageEnglish
    Pages (from-to)1135 - 1140
    Number of pages6
    JournalEuropean Journal of Gastroenterology and Hepatology
    Volume12
    Issue number10
    DOIs
    Publication statusPublished - 2000

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