Granulocytes and mast cells in AllergoOncology-Bridging allergy to cancer: An EAACI position paper

Mariona Pascal, Heather J Bax, Christoph Bergmann, Rodolfo Bianchini, Mariana Castells, Jitesh Chauhan, Leticia De Las Vecillas, Karin Hartmann, Elena Izquierdo Álvarez, Uta Jappe, Teodorikez-Wilfox Jimenez-Rodriguez, Edward Knol, Francesca Levi-Schaffer, Cristobalina Mayorga, Aurélie Poli, Frank Redegeld, Alexandra F Santos, Erika Jensen-Jarolim, Sophia N Karagiannis

Research output: Contribution to journalArticlepeer-review

11 Downloads (Pure)

Abstract

Derived from the myeloid lineage, granulocytes, including basophils, eosinophils, and neutrophils, along with mast cells, play important, often disparate, roles across the allergic disease spectrum. While these cells and their mediators are commonly associated with allergic inflammation, they also exhibit several functions either promoting or restricting tumor growth. In this Position Paper we discuss common granulocyte and mast cell features relating to immunomodulatory functions in allergy and in cancer. We highlight key mechanisms which may inform cancer treatment and propose pertinent areas for future research. We suggest areas where understanding the communication between granulocytes, mast cells, and the tumor microenvironment, will be crucial for identifying immune mechanisms that may be harnessed to counteract tumor development. For example, a comprehensive understanding of allergic and immune factors driving distinct neutrophil states and those mechanisms that link mast cells with immunotherapy resistance, might enable targeted manipulation of specific subpopulations, leading to precision immunotherapy in cancer. We recommend specific areas of investigation in AllergoOncology and knowledge exchange across disease contexts to uncover pertinent reciprocal functions in allergy and cancer and allow therapeutic manipulation of these powerful cell populations. These will help address the unmet needs in stratifying and managing patients with allergic diseases and cancer.

Original languageEnglish
Pages (from-to)2319-2345
Number of pages27
JournalAllergy
Volume79
Issue number9
Early online date22 Jul 2024
DOIs
Publication statusPublished - Sept 2024

Fingerprint

Dive into the research topics of 'Granulocytes and mast cells in AllergoOncology-Bridging allergy to cancer: An EAACI position paper'. Together they form a unique fingerprint.

Cite this