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Grey matter volume and thickness abnormalities in young people with a history of childhood abuse

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)1-13
JournalPsychological Medicine
Early online date10 Nov 2017
Accepted/In press25 Jul 2017
E-pub ahead of print10 Nov 2017


  • Grey matter volume_LIM_Accepted25July2017_GREEN AAM

    Grey_matter_volume_LIM_Accepted25July2017_GREEN_AAM.pdf, 2.35 MB, application/pdf

    Uploaded date:30 Aug 2017

    Version:Accepted author manuscript

    This is the peer-reviewed manuscript of a paper accepted for publication in Psychological Medicine, © Cambridge University Press 2017

King's Authors


Background: Childhood abuse is associated with abnormalities in brain structure and function. Few studies have investigated abuse-related brain abnormalities in medication-naïve, drug-free youth that also controlled for psychiatric comorbidities by inclusion of a psychiatric control group, which is crucial to disentangle the effects of abuse from those associated with the psychiatric conditions.

Methods: Cortical volume (CV), cortical thickness (CT) and surface area (SA) were measured in 22 age-and gender-matched medication-naïve youth (aged 13-20) exposed to childhood abuse, 19 psychiatric controls matched for psychiatric diagnoses and 27 healthy controls. Both region-of-interest (ROI) and whole-brain analyses were conducted.

Results: For the ROI analysis, the childhood abuse group compared to healthy controls only, had significantly reduced CV in bilateral cerebellum and reduced CT in left insula and right lateral orbitofrontal cortex (OFC). At the whole-brain level, relative to healthy controls, the childhood abuse group showed significantly reduced CV in left lingual, pericalcarine, precuneus and superior parietal gyri, and reduced CT in left pre-/postcentral and paracentral regions, which furthermore correlated with greater abuse severity. They also had increased CV in left inferior and middle temporal gyri relative to healthy controls. Abnormalities in the precuneus, temporal and precentral regions were abuse-specific relative to psychiatric controls, albeit at a more lenient level. Groups did not differ in SA.

Conclusions: Childhood abuse is associated with widespread structural abnormalities in OFC-insular, cerebellar, occipital, parietal and temporal regions, which likely underlie the abnormal affective, motivational and cognitive functions typically observed in this population.

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