Growing functions of the ESCRT machinery in cell biology and viral replication

Edward J. Scourfield; Juan Martin-Serrano

doi:10.1042/BST20160479

Growing functions of the ESCRT machinery in cell biology and viral replication

Edward J. Scourfield, Juan Martin-Serrano^*

^*Corresponding author for this work

Infectious Diseases

Research output: Contribution to journal › Review article › peer-review

65 Citations (Scopus)

Abstract

The vast expansion in recent years of the cellular processes promoted by the endosomal sorting complex required for transport (ESCRT) machinery has reinforced its identity as a modular system that uses multiple adaptors to recruit the core membrane remodelling activity at different intracellular sites and facilitate membrane scission. Functional connections to processes such as the aurora B-dependent abscission checkpoint also highlight the importance of the spatiotemporal regulation of the ESCRT machinery. Here, we summarise the role of ESCRTs in viral budding, and what we have learned about the ESCRT pathway from studying this process. These advances are discussed in the context of areas of cell biology that have been transformed by research in the ESCRT field, including cytokinetic abscission, nuclear envelope resealing and plasma membrane repair.

Original language	English
Pages (from-to)	613-634
Number of pages	22
Journal	Biochemical Society Transactions
Volume	45
Issue number	3
DOIs	https://doi.org/10.1042/BST20160479
Publication status	Published - 15 Jun 2017

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AB - The vast expansion in recent years of the cellular processes promoted by the endosomal sorting complex required for transport (ESCRT) machinery has reinforced its identity as a modular system that uses multiple adaptors to recruit the core membrane remodelling activity at different intracellular sites and facilitate membrane scission. Functional connections to processes such as the aurora B-dependent abscission checkpoint also highlight the importance of the spatiotemporal regulation of the ESCRT machinery. Here, we summarise the role of ESCRTs in viral budding, and what we have learned about the ESCRT pathway from studying this process. These advances are discussed in the context of areas of cell biology that have been transformed by research in the ESCRT field, including cytokinetic abscission, nuclear envelope resealing and plasma membrane repair.

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Growing functions of the ESCRT machinery in cell biology and viral replication

Abstract

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