Abstract
Cells are able to adjust their growth and size to external inputs to comply with specific fates and developmental programs. Molecular pathways controlling growth also have an enormous impact in cell size, and bacteria, yeast, or epithelial cells modify their size as a function of growth rate. This universal feature suggests that growth (mass) and proliferation (cell number) rates are subject to general coordinating mechanisms. However, the underlying molecular connections are still a matter of debate. Here we review the current ideas on growth and cell size control, and focus on the possible mechanisms that could link the biosynthetic machinery to the Start network in budding yeast. In particular, we discuss the role of molecular chaperones in a competition framework to explain cell size control by growth at the individual cell level.
Original language | English |
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Article number | 57 |
Number of pages | 6 |
Journal | Frontiers in Cell and Developmental Biology |
Volume | 5 |
Issue number | MAY |
Early online date | 26 May 2017 |
DOIs | |
Publication status | E-pub ahead of print - 26 May 2017 |
Keywords
- Budding yeast
- Cell cycle
- Cell size
- Mathematical model
- Size control