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Growth rate as a direct regulator of the start network to set cell size

Research output: Contribution to journalShort survey

Original languageEnglish
Article number57
Number of pages6
JournalFrontiers in Cell and Developmental Biology
Volume5
Issue numberMAY
Early online date26 May 2017
DOIs
Publication statusE-pub ahead of print - 26 May 2017

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Abstract

Cells are able to adjust their growth and size to external inputs to comply with specific fates and developmental programs. Molecular pathways controlling growth also have an enormous impact in cell size, and bacteria, yeast, or epithelial cells modify their size as a function of growth rate. This universal feature suggests that growth (mass) and proliferation (cell number) rates are subject to general coordinating mechanisms. However, the underlying molecular connections are still a matter of debate. Here we review the current ideas on growth and cell size control, and focus on the possible mechanisms that could link the biosynthetic machinery to the Start network in budding yeast. In particular, we discuss the role of molecular chaperones in a competition framework to explain cell size control by growth at the individual cell level.

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