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Growth rate as a direct regulator of the start network to set cell size

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Growth rate as a direct regulator of the start network to set cell size. / Aldea, Martí; Jenkins, Kirsten; Csikász-Nagy, Attila.

In: Frontiers in Cell and Developmental Biology, Vol. 5, No. MAY, 57, 26.05.2017.

Research output: Contribution to journalShort survey

Harvard

Aldea, M, Jenkins, K & Csikász-Nagy, A 2017, 'Growth rate as a direct regulator of the start network to set cell size', Frontiers in Cell and Developmental Biology, vol. 5, no. MAY, 57. https://doi.org/10.3389/fcell.2017.00057

APA

Aldea, M., Jenkins, K., & Csikász-Nagy, A. (2017). Growth rate as a direct regulator of the start network to set cell size. Frontiers in Cell and Developmental Biology, 5(MAY), [57]. https://doi.org/10.3389/fcell.2017.00057

Vancouver

Aldea M, Jenkins K, Csikász-Nagy A. Growth rate as a direct regulator of the start network to set cell size. Frontiers in Cell and Developmental Biology. 2017 May 26;5(MAY). 57. https://doi.org/10.3389/fcell.2017.00057

Author

Aldea, Martí ; Jenkins, Kirsten ; Csikász-Nagy, Attila. / Growth rate as a direct regulator of the start network to set cell size. In: Frontiers in Cell and Developmental Biology. 2017 ; Vol. 5, No. MAY.

Bibtex Download

@article{bbafee906ece4c2d9eb318576b492d9a,
title = "Growth rate as a direct regulator of the start network to set cell size",
abstract = "Cells are able to adjust their growth and size to external inputs to comply with specific fates and developmental programs. Molecular pathways controlling growth also have an enormous impact in cell size, and bacteria, yeast, or epithelial cells modify their size as a function of growth rate. This universal feature suggests that growth (mass) and proliferation (cell number) rates are subject to general coordinating mechanisms. However, the underlying molecular connections are still a matter of debate. Here we review the current ideas on growth and cell size control, and focus on the possible mechanisms that could link the biosynthetic machinery to the Start network in budding yeast. In particular, we discuss the role of molecular chaperones in a competition framework to explain cell size control by growth at the individual cell level.",
keywords = "Budding yeast, Cell cycle, Cell size, Mathematical model, Size control",
author = "Mart{\'i} Aldea and Kirsten Jenkins and Attila Csik{\'a}sz-Nagy",
year = "2017",
month = "5",
day = "26",
doi = "10.3389/fcell.2017.00057",
language = "English",
volume = "5",
journal = "Frontiers in Cell and Developmental Biology",
issn = "2296-634X",
publisher = "Frontiers Media S.A.",
number = "MAY",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Growth rate as a direct regulator of the start network to set cell size

AU - Aldea, Martí

AU - Jenkins, Kirsten

AU - Csikász-Nagy, Attila

PY - 2017/5/26

Y1 - 2017/5/26

N2 - Cells are able to adjust their growth and size to external inputs to comply with specific fates and developmental programs. Molecular pathways controlling growth also have an enormous impact in cell size, and bacteria, yeast, or epithelial cells modify their size as a function of growth rate. This universal feature suggests that growth (mass) and proliferation (cell number) rates are subject to general coordinating mechanisms. However, the underlying molecular connections are still a matter of debate. Here we review the current ideas on growth and cell size control, and focus on the possible mechanisms that could link the biosynthetic machinery to the Start network in budding yeast. In particular, we discuss the role of molecular chaperones in a competition framework to explain cell size control by growth at the individual cell level.

AB - Cells are able to adjust their growth and size to external inputs to comply with specific fates and developmental programs. Molecular pathways controlling growth also have an enormous impact in cell size, and bacteria, yeast, or epithelial cells modify their size as a function of growth rate. This universal feature suggests that growth (mass) and proliferation (cell number) rates are subject to general coordinating mechanisms. However, the underlying molecular connections are still a matter of debate. Here we review the current ideas on growth and cell size control, and focus on the possible mechanisms that could link the biosynthetic machinery to the Start network in budding yeast. In particular, we discuss the role of molecular chaperones in a competition framework to explain cell size control by growth at the individual cell level.

KW - Budding yeast

KW - Cell cycle

KW - Cell size

KW - Mathematical model

KW - Size control

UR - http://www.scopus.com/inward/record.url?scp=85026822809&partnerID=8YFLogxK

U2 - 10.3389/fcell.2017.00057

DO - 10.3389/fcell.2017.00057

M3 - Short survey

AN - SCOPUS:85026822809

VL - 5

JO - Frontiers in Cell and Developmental Biology

JF - Frontiers in Cell and Developmental Biology

SN - 2296-634X

IS - MAY

M1 - 57

ER -

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