Guidance on the use of PET for treatment planning in radiotherapy clinical trials

TY - JOUR

T1 - Guidance on the use of PET for treatment planning in radiotherapy clinical trials

AU - Pike, Lucy

AU - Thomas, Christopher

AU - Guerrero-Urbano, Maria Teresa

AU - Michaelidou, Andriana

AU - Greener, Tony

AU - Miles, Elizabeth

AU - Eaton, David

AU - Barrington, Sally Fiona

PY - 2019/11/1

Y1 - 2019/11/1

N2 - The aim of this article is to propose meaningful guidance covering the practical and technical issues involved when planning or conducting clinical trials involving positron emission tomography (PET) guided radiotherapy. The complexity of imaging requirements will depend on the study aims, design and PET methods used. Where PET is used to adapt radiotherapy, a high level of accuracy and reproducibility is required to ensure effective and safe treatment delivery. The guidance in this document is intended to assist researchers designing clinical trials involving PET guided radiotherapy to provide sufficient information about the appropriate methods to complete PET-CT imaging to a consistent standard at participating centres. The guidance is divided into six categories: application of PET in radiotherapy, resource requirements, quality assurance (QA), imaging protocol design, data management and image processing. Each section provides an overview of the recent literature to support the specific recommendations. This guidance builds on previous recommendations from the National Cancer Research Institute (NCRI) PET Research Network and has been produced in collaboration with the National Radiotherapy Trials Quality Assurance Group (RTTQA).

AB - The aim of this article is to propose meaningful guidance covering the practical and technical issues involved when planning or conducting clinical trials involving positron emission tomography (PET) guided radiotherapy. The complexity of imaging requirements will depend on the study aims, design and PET methods used. Where PET is used to adapt radiotherapy, a high level of accuracy and reproducibility is required to ensure effective and safe treatment delivery. The guidance in this document is intended to assist researchers designing clinical trials involving PET guided radiotherapy to provide sufficient information about the appropriate methods to complete PET-CT imaging to a consistent standard at participating centres. The guidance is divided into six categories: application of PET in radiotherapy, resource requirements, quality assurance (QA), imaging protocol design, data management and image processing. Each section provides an overview of the recent literature to support the specific recommendations. This guidance builds on previous recommendations from the National Cancer Research Institute (NCRI) PET Research Network and has been produced in collaboration with the National Radiotherapy Trials Quality Assurance Group (RTTQA).

UR - http://www.scopus.com/inward/record.url?scp=85073663842&partnerID=8YFLogxK

U2 - 10.1259/bjr.20190180

DO - 10.1259/bjr.20190180

M3 - Review article

SN - 0007-1285

VL - 92

JO - British Journal of Radiology

JF - British Journal of Radiology

IS - 1103

M1 - 20190180

ER -