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Guidance on the use of PET for treatment planning in radiotherapy clinical trials

Research output: Contribution to journalReview articlepeer-review

Lucy Pike, Christopher Thomas, Maria Teresa Guerrero-Urbano, Andriana Michaelidou, Tony Greener, Elizabeth Miles, David Eaton, Sally Fiona Barrington

Original languageEnglish
Article number20190180
Number of pages1
JournalBritish Journal of Radiology
Issue number1103
Early online date23 Aug 2019
Accepted/In press20 Aug 2019
E-pub ahead of print23 Aug 2019
Published1 Nov 2019


King's Authors


The aim of this article is to propose meaningful guidance covering the practical and technical issues involved when planning or conducting clinical trials involving positron emission tomography (PET) guided radiotherapy. The complexity of imaging requirements will depend on the study aims, design and PET methods used. Where PET is used to adapt radiotherapy, a high level of accuracy and reproducibility is required to ensure effective and safe treatment delivery. The guidance in this document is intended to assist researchers designing clinical trials involving PET guided radiotherapy to provide sufficient information about the appropriate methods to complete PET-CT imaging to a consistent standard at participating centres. The guidance is divided into six categories: application of PET in radiotherapy, resource requirements, quality assurance (QA), imaging protocol design, data management and image processing. Each section provides an overview of the recent literature to support the specific recommendations. This guidance builds on previous recommendations from the National Cancer Research Institute (NCRI) PET Research Network and has been produced in collaboration with the National Radiotherapy Trials Quality Assurance Group (RTTQA).

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