Guidelines to PET measurements of the target occupancy in the brain for drug development

Akihiro Takano; Andrea Varrone; Balázs Gulyás; Piero Salvadori; Antony Gee; Albert Windhorst; Johnny Vercouillie; Guy Bormans; Adriaan A. Lammertsma; Christer Halldin

doi:10.1007/s00259-016-3476-4

Guidelines to PET measurements of the target occupancy in the brain for drug development

Akihiro Takano^*, Andrea Varrone, Balázs Gulyás, Piero Salvadori, Antony Gee, Albert Windhorst, Johnny Vercouillie, Guy Bormans, Adriaan A. Lammertsma, Christer Halldin

^*Corresponding author for this work

Imaging Chemistry & Biology

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Abstract

This guideline summarizes the current view of the European Association of Nuclear Medicine Drug Development Committee. The purpose of this guideline is to guarantee a high standard of PET studies that are aimed at measuring target occupancy in the brain within the framework of development programs of drugs that act within the central nervous system (CNS drugs). This guideline is intended to present information specifically adapted to European practice. The information provided should be applied within the context of local conditions and regulations.

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	European Journal of Nuclear Medicine and Molecular Imaging
Early online date	11 Aug 2016
DOIs	https://doi.org/10.1007/s00259-016-3476-4
Publication status	E-pub ahead of print - 11 Aug 2016

Keywords

Drug development
Positron emission tomography
Target occupancy

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Guidelines to PET measurements_TAKANO_Accepted25July2016_GOLD VoRFinal published version, 519 KB

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Takano, A., Varrone, A., Gulyás, B., Salvadori, P., Gee, A., Windhorst, A., Vercouillie, J., Bormans, G., Lammertsma, A. A., & Halldin, C. (2016). Guidelines to PET measurements of the target occupancy in the brain for drug development. European Journal of Nuclear Medicine and Molecular Imaging, 1-8. Advance online publication. https://doi.org/10.1007/s00259-016-3476-4

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AU - Gee, Antony

AU - Windhorst, Albert

AU - Vercouillie, Johnny

AU - Bormans, Guy

AU - Lammertsma, Adriaan A.

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Guidelines to PET measurements of the target occupancy in the brain for drug development

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Keywords

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