Guidelines to PET measurements of the target occupancy in the brain for drug development

Akihiro Takano*, Andrea Varrone, Balázs Gulyás, Piero Salvadori, Antony Gee, Albert Windhorst, Johnny Vercouillie, Guy Bormans, Adriaan A. Lammertsma, Christer Halldin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)
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This guideline summarizes the current view of the European Association of Nuclear Medicine Drug Development Committee. The purpose of this guideline is to guarantee a high standard of PET studies that are aimed at measuring target occupancy in the brain within the framework of development programs of drugs that act within the central nervous system (CNS drugs). This guideline is intended to present information specifically adapted to European practice. The information provided should be applied within the context of local conditions and regulations.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Early online date11 Aug 2016
Publication statusE-pub ahead of print - 11 Aug 2016


  • Drug development
  • Positron emission tomography
  • Target occupancy


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