Gut Microbiome in Liver Transplantation: From Preoperative Status to Posttransplant Outcomes

Sunitha Vimalesvaran; Maha A. Abdulla; Eirini Kyrana

doi:10.1111/petr.70128

Gut Microbiome in Liver Transplantation: From Preoperative Status to Posttransplant Outcomes

Sunitha Vimalesvaran^*
, Maha A. Abdulla
, Eirini Kyrana

^*Corresponding author for this work

Roger Williams Inst. of Liver Studies

KCH King's College Hospital NHS Foundation Trust
Sidra Medicine
Paediatric Liver
Faculty of Life Sciences & Medicine
GSTT Guy's and St Thomas' NHS Foundation Trust

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

Liver transplantation remains the gold standard treatment for patients with end-stage liver disease. Despite significant improvement in surgical care and postoperative medical care, complications in the posttransplant period remain a concern. Graft rejection due to immunological factors is associated with increased morbidity and mortality. Infectious complications also have a major impact on patient outcomes. There is growing evidence about the role of the gut microbiome in the perioperative liver transplant course and the impact on patient outcomes in liver transplantation. These patients often already have gut dysbiosis at the time of liver transplantation due to their severe underlying disease and the use of repeated antibiotic courses. In this comprehensive review, we compile the current evidence for the role of the gut microbiome during the liver transplantation period.

Original language	English
Article number	e70128
Journal	PEDIATRIC TRANSPLANTATION
Volume	29
Issue number	5
DOIs	https://doi.org/10.1111/petr.70128
Publication status	Published - Aug 2025

Keywords

gut microbiome
liver transplantation
pediatric

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10.1111/petr.70128

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title = "Gut Microbiome in Liver Transplantation: From Preoperative Status to Posttransplant Outcomes",

abstract = "Liver transplantation remains the gold standard treatment for patients with end-stage liver disease. Despite significant improvement in surgical care and postoperative medical care, complications in the posttransplant period remain a concern. Graft rejection due to immunological factors is associated with increased morbidity and mortality. Infectious complications also have a major impact on patient outcomes. There is growing evidence about the role of the gut microbiome in the perioperative liver transplant course and the impact on patient outcomes in liver transplantation. These patients often already have gut dysbiosis at the time of liver transplantation due to their severe underlying disease and the use of repeated antibiotic courses. In this comprehensive review, we compile the current evidence for the role of the gut microbiome during the liver transplantation period.",

keywords = "gut microbiome, liver transplantation, pediatric",

author = "Sunitha Vimalesvaran and Abdulla, \{Maha A.\} and Eirini Kyrana",

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T1 - Gut Microbiome in Liver Transplantation

T2 - From Preoperative Status to Posttransplant Outcomes

AU - Vimalesvaran, Sunitha

AU - Abdulla, Maha A.

AU - Kyrana, Eirini

PY - 2025/8

Y1 - 2025/8

N2 - Liver transplantation remains the gold standard treatment for patients with end-stage liver disease. Despite significant improvement in surgical care and postoperative medical care, complications in the posttransplant period remain a concern. Graft rejection due to immunological factors is associated with increased morbidity and mortality. Infectious complications also have a major impact on patient outcomes. There is growing evidence about the role of the gut microbiome in the perioperative liver transplant course and the impact on patient outcomes in liver transplantation. These patients often already have gut dysbiosis at the time of liver transplantation due to their severe underlying disease and the use of repeated antibiotic courses. In this comprehensive review, we compile the current evidence for the role of the gut microbiome during the liver transplantation period.

AB - Liver transplantation remains the gold standard treatment for patients with end-stage liver disease. Despite significant improvement in surgical care and postoperative medical care, complications in the posttransplant period remain a concern. Graft rejection due to immunological factors is associated with increased morbidity and mortality. Infectious complications also have a major impact on patient outcomes. There is growing evidence about the role of the gut microbiome in the perioperative liver transplant course and the impact on patient outcomes in liver transplantation. These patients often already have gut dysbiosis at the time of liver transplantation due to their severe underlying disease and the use of repeated antibiotic courses. In this comprehensive review, we compile the current evidence for the role of the gut microbiome during the liver transplantation period.

KW - gut microbiome

KW - liver transplantation

KW - pediatric

UR - https://www.scopus.com/pages/publications/105011270064

U2 - 10.1111/petr.70128

DO - 10.1111/petr.70128

M3 - Review article

C2 - 40698732

AN - SCOPUS:105011270064

SN - 1397-3142

VL - 29

JO - PEDIATRIC TRANSPLANTATION

JF - PEDIATRIC TRANSPLANTATION

IS - 5

M1 - e70128

ER -

Gut Microbiome in Liver Transplantation: From Preoperative Status to Posttransplant Outcomes

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Keywords

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