Gut microbiota associations with common diseases and prescription medications in a population-based cohort

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Abstract

The human gut microbiome has been associated with many health factors but variability between studies limits exploration of effects between them. Gut microbiota profiles are available for >2700 members of the deeply phenotyped TwinsUK cohort, providing a uniform platform for such comparisons. Here, we present gut microbiota association analyses for 38 common diseases and 51 medications within the cohort. We describe several novel associations, highlight associations common across multiple diseases, and determine which diseases and medications have the greatest association with the gut microbiota. These results provide a reference for future studies of the gut microbiome and its role in human health.
Original languageEnglish
Article number2655
Number of pages8
JournalNature Communications
Volume9
Issue number1
Early online date9 Jul 2018
DOIs
Publication statusE-pub ahead of print - 9 Jul 2018

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