H-1-NMR STUDIES OF THE INTERACTIONS OF 2 DISTAMYCIN ANALOGS WITH THE DODECAMER D(CGCGAATTCGCG)2

M R  CONTE; E  FATTORUSSO; L G  PALOMA; L  MAYOL

doi:10.1016/S0960-894X(00)80234-6

H-1-NMR STUDIES OF THE INTERACTIONS OF 2 DISTAMYCIN ANALOGS WITH THE DODECAMER D(CGCGAATTCGCG)2

M R CONTE, E FATTORUSSO, L G PALOMA, L MAYOL

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5 Citations (Scopus)

Abstract

High resolution proton NMR techniques have been used to study the interaction between the self complementary Dickerson dodecamer d(CGCGAATTCGCG)2 and two distamycin analogues containing a retroinverted amide bond. The results indicated that both analogues, although binding the Dickerson dodecamer less strongly than distamycin, span the central AATT segment in the minor groove in a similar fashion.

Original language	English
Pages (from-to)	1299-1304
Number of pages	6
Journal	BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS
Volume	2
Issue number	10
DOIs	https://doi.org/10.1016/S0960-894X(00)80234-6
Publication status	Published - Oct 1992

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title = "H-1-NMR STUDIES OF THE INTERACTIONS OF 2 DISTAMYCIN ANALOGS WITH THE DODECAMER D(CGCGAATTCGCG)2",

abstract = "High resolution proton NMR techniques have been used to study the interaction between the self complementary Dickerson dodecamer d(CGCGAATTCGCG)2 and two distamycin analogues containing a retroinverted amide bond. The results indicated that both analogues, although binding the Dickerson dodecamer less strongly than distamycin, span the central AATT segment in the minor groove in a similar fashion.",

author = "CONTE, {M R} and E FATTORUSSO and PALOMA, {L G} and L MAYOL",

year = "1992",

month = oct,

doi = "10.1016/S0960-894X(00)80234-6",

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AU - CONTE, M R

AU - FATTORUSSO, E

AU - PALOMA, L G

AU - MAYOL, L

PY - 1992/10

Y1 - 1992/10

N2 - High resolution proton NMR techniques have been used to study the interaction between the self complementary Dickerson dodecamer d(CGCGAATTCGCG)2 and two distamycin analogues containing a retroinverted amide bond. The results indicated that both analogues, although binding the Dickerson dodecamer less strongly than distamycin, span the central AATT segment in the minor groove in a similar fashion.

AB - High resolution proton NMR techniques have been used to study the interaction between the self complementary Dickerson dodecamer d(CGCGAATTCGCG)2 and two distamycin analogues containing a retroinverted amide bond. The results indicated that both analogues, although binding the Dickerson dodecamer less strongly than distamycin, span the central AATT segment in the minor groove in a similar fashion.

U2 - 10.1016/S0960-894X(00)80234-6

DO - 10.1016/S0960-894X(00)80234-6

M3 - Article

SN - 0960-894X

VL - 2

SP - 1299

EP - 1304

JO - BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS

JF - BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS

IS - 10

ER -

H-1-NMR STUDIES OF THE INTERACTIONS OF 2 DISTAMYCIN ANALOGS WITH THE DODECAMER D(CGCGAATTCGCG)2

Abstract

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