TY - JOUR
T1 - Hallmarks of Cancer Applied to Oral and Oropharyngeal Carcinogenesis
T2 - A Scoping Review of the Evidence Gaps Found in Published Systematic Reviews
AU - González-Moles, Miguel Ángel
AU - Warnakulasuriya, Saman
AU - López-Ansio, María
AU - Ramos-García, Pablo
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/8
Y1 - 2022/8
N2 - In 2000 and 2011, Hanahan and Weinberg published two papers in which they defined the characteristics that cells must fulfil in order to be considered neoplastic cells in all types of tumours that affect humans, which the authors called “hallmarks of cancer”. These papers have represented a milestone in our understanding of the biology of many types of cancers and have made it possible to reach high levels of scientific evidence in relation to the prognostic impact that these hallmarks have on different tumour types. However, to date, there is no study that globally analyses evidence-based knowledge on the importance of these hallmarks in oral and oropharyngeal squamous cell carcinomas. For this reason, we set out to conduct this scoping review of systematic reviews with the aim of detecting evidence gaps in relation to the relevance of the cancer hallmarks proposed by Hanahan and Weinberg in oral and oropharyngeal cancer, and oral potentially malignant disorders, and to point out future lines of research in this field.
AB - In 2000 and 2011, Hanahan and Weinberg published two papers in which they defined the characteristics that cells must fulfil in order to be considered neoplastic cells in all types of tumours that affect humans, which the authors called “hallmarks of cancer”. These papers have represented a milestone in our understanding of the biology of many types of cancers and have made it possible to reach high levels of scientific evidence in relation to the prognostic impact that these hallmarks have on different tumour types. However, to date, there is no study that globally analyses evidence-based knowledge on the importance of these hallmarks in oral and oropharyngeal squamous cell carcinomas. For this reason, we set out to conduct this scoping review of systematic reviews with the aim of detecting evidence gaps in relation to the relevance of the cancer hallmarks proposed by Hanahan and Weinberg in oral and oropharyngeal cancer, and oral potentially malignant disorders, and to point out future lines of research in this field.
KW - biomarkers
KW - hallmarks of cancer
KW - meta-analysis
KW - oral cancer
KW - oral potentially malignant disorders
KW - oropharyngeal cancer
KW - scoping review
KW - systematic review
UR - http://www.scopus.com/inward/record.url?scp=85136586044&partnerID=8YFLogxK
U2 - 10.3390/cancers14153834
DO - 10.3390/cancers14153834
M3 - Review article
AN - SCOPUS:85136586044
SN - 2072-6694
VL - 14
JO - Cancers
JF - Cancers
IS - 15
M1 - 3834
ER -
