Health associations of liver enzymes and inflammatory scores with urinary citrus flavonoid metabolites

Vanessa Bullón-Vela; Yifan Xu; Cristina Razquin; Itziar Abete; Maria Angeles Zulet; Miguel A Martínez-González; Pilar Buil-Corsiales; Facundo Vitelli-Storelli; Vicente Martín Sánchez; Zenaida Vazquez-Ruíz; Carmen Sayón-Orea; Maite Domínguez-Fernández; Concepción Cid; Ramon Estruch; Rosa María Lamuela-Raventós; Montserrat Fitó; Gemma Blanchart; Nancy Babio; Jordi Salas-Salvadó; Francisco J Tinahones; Josep A Tur; Dora Romaguera; Jadwiga Konieczna; Xavier Pintó; Lidia Daimiel; Ana Rodriguez-Mateos; José Alfredo Martínez

doi:10.1039/d2fo02846h

Health associations of liver enzymes and inflammatory scores with urinary citrus flavonoid metabolites

Vanessa Bullón-Vela, Yifan Xu, Cristina Razquin, Itziar Abete, Maria Angeles Zulet, Miguel A Martínez-González, Pilar Buil-Corsiales, Facundo Vitelli-Storelli, Vicente Martín Sánchez, Zenaida Vazquez-Ruíz, Carmen Sayón-Orea, Maite Domínguez-Fernández, Concepción Cid, Ramon Estruch, Rosa María Lamuela-Raventós, Montserrat Fitó, Gemma Blanchart, Nancy Babio, Jordi Salas-Salvadó, Francisco J TinahonesJosep A Tur, Dora Romaguera, Jadwiga Konieczna, Xavier Pintó, Lidia Daimiel, Ana Rodriguez-Mateos, José Alfredo Martínez

Nutritional Sciences

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Abstract

Background: Dietary flavonoid intake is associated with a reduced risk of some cardiometabolic disorders, attributed in part to their claimed anti-inflammatory activity. Our aim was to investigate the potential association between specific urine flavonoid metabolites, liver enzymes, and inflammatory status in individuals with metabolic syndrome (MetS). Methods: In this cross-sectional study, clinical and dietary data from 267 participants, aged 55 to 75 years, participating in the PREDIMED Plus study (PREvención con DIeta MEDiterránea) were analyzed. At the baseline, spot urine samples were collected and seven urinary flavonoid metabolites were quantified using ultra-performance liquid chromatography coupled to triple quadrupole mass spectrometry (UPLC-Q-q-Q MS). Liver enzymes, inflammatory scores, and urinary flavonoid concentrations were inverse normally transformed. Results: Adjusted linear regression models showed an inverse association between urinary citrus flavanone concentrations and gamma-glutamyl transferase (GGT) (all p-values <0.05). Naringenin 7'-GlcUA was significantly associated with a lower aggregate index of systemic inflammation (AISI) (Bper 1SD = -0.14; 95% CI: -0.27 to -0.02; p-value = 0.025) and systemic inflammation index (SII) (Bper 1SD = -0.14; 95% CI: -0.27 to -0.02; p-value = 0.028). To investigate the relationship between flavanone subclasses and GGT levels, we fitted a score of citrus-flavanones, and subjects were stratified into quartiles. The highest values of the citrus-flavanone score (per 1-SD increase) were associated with lower GGT levels (Bper 1SD = -0.41; 95% CI: -0.74 to -0.07), exhibiting a linear trend across quartiles (p-trend = 0.015). Conclusion: This cross-sectional study showed that higher urinary excretion of citrus-flavanone metabolites was associated with lower GGT levels in subjects diagnosed with MetS and obesity.

Original language	English
Journal	Food & Function
Early online date	23 Dec 2022
DOIs	https://doi.org/10.1039/d2fo02846h
Publication status	E-pub ahead of print - 23 Dec 2022

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Bullón-Vela, V., Xu, Y., Razquin, C., Abete, I., Zulet, M. A., Martínez-González, M. A., Buil-Corsiales, P., Vitelli-Storelli, F., Martín Sánchez, V., Vazquez-Ruíz, Z., Sayón-Orea, C., Domínguez-Fernández, M., Cid, C., Estruch, R., Lamuela-Raventós, R. M., Fitó, M., Blanchart, G., Babio, N., Salas-Salvadó, J., ... Martínez, J. A. (2022). Health associations of liver enzymes and inflammatory scores with urinary citrus flavonoid metabolites. Food & Function. Advance online publication. https://doi.org/10.1039/d2fo02846h

@article{579c84a5bcaf410ab0188dd99845b346,

title = "Health associations of liver enzymes and inflammatory scores with urinary citrus flavonoid metabolites",

abstract = "Background: Dietary flavonoid intake is associated with a reduced risk of some cardiometabolic disorders, attributed in part to their claimed anti-inflammatory activity. Our aim was to investigate the potential association between specific urine flavonoid metabolites, liver enzymes, and inflammatory status in individuals with metabolic syndrome (MetS). Methods: In this cross-sectional study, clinical and dietary data from 267 participants, aged 55 to 75 years, participating in the PREDIMED Plus study (PREvenci{\'o}n con DIeta MEDiterr{\'a}nea) were analyzed. At the baseline, spot urine samples were collected and seven urinary flavonoid metabolites were quantified using ultra-performance liquid chromatography coupled to triple quadrupole mass spectrometry (UPLC-Q-q-Q MS). Liver enzymes, inflammatory scores, and urinary flavonoid concentrations were inverse normally transformed. Results: Adjusted linear regression models showed an inverse association between urinary citrus flavanone concentrations and gamma-glutamyl transferase (GGT) (all p-values <0.05). Naringenin 7'-GlcUA was significantly associated with a lower aggregate index of systemic inflammation (AISI) (Bper 1SD = -0.14; 95% CI: -0.27 to -0.02; p-value = 0.025) and systemic inflammation index (SII) (Bper 1SD = -0.14; 95% CI: -0.27 to -0.02; p-value = 0.028). To investigate the relationship between flavanone subclasses and GGT levels, we fitted a score of citrus-flavanones, and subjects were stratified into quartiles. The highest values of the citrus-flavanone score (per 1-SD increase) were associated with lower GGT levels (Bper 1SD = -0.41; 95% CI: -0.74 to -0.07), exhibiting a linear trend across quartiles (p-trend = 0.015). Conclusion: This cross-sectional study showed that higher urinary excretion of citrus-flavanone metabolites was associated with lower GGT levels in subjects diagnosed with MetS and obesity.",

author = "Vanessa Bull{\'o}n-Vela and Yifan Xu and Cristina Razquin and Itziar Abete and Zulet, {Maria Angeles} and Mart{\'i}nez-Gonz{\'a}lez, {Miguel A} and Pilar Buil-Corsiales and Facundo Vitelli-Storelli and {Mart{\'i}n S{\'a}nchez}, Vicente and Zenaida Vazquez-Ru{\'i}z and Carmen Say{\'o}n-Orea and Maite Dom{\'i}nguez-Fern{\'a}ndez and Concepci{\'o}n Cid and Ramon Estruch and Lamuela-Ravent{\'o}s, {Rosa Mar{\'i}a} and Montserrat Fit{\'o} and Gemma Blanchart and Nancy Babio and Jordi Salas-Salvad{\'o} and Tinahones, {Francisco J} and Tur, {Josep A} and Dora Romaguera and Jadwiga Konieczna and Xavier Pint{\'o} and Lidia Daimiel and Ana Rodriguez-Mateos and Mart{\'i}nez, {Jos{\'e} Alfredo}",

year = "2022",

month = dec,

day = "23",

doi = "10.1039/d2fo02846h",

language = "English",

journal = "Food & Function",

issn = "2042-6496",

publisher = "Royal Society of Chemistry",

}

Bullón-Vela, V, Xu, Y, Razquin, C, Abete, I, Zulet, MA, Martínez-González, MA, Buil-Corsiales, P, Vitelli-Storelli, F, Martín Sánchez, V, Vazquez-Ruíz, Z, Sayón-Orea, C, Domínguez-Fernández, M, Cid, C, Estruch, R, Lamuela-Raventós, RM, Fitó, M, Blanchart, G, Babio, N, Salas-Salvadó, J, Tinahones, FJ, Tur, JA, Romaguera, D, Konieczna, J, Pintó, X, Daimiel, L, Rodriguez-Mateos, A & Martínez, JA 2022, 'Health associations of liver enzymes and inflammatory scores with urinary citrus flavonoid metabolites', Food & Function. https://doi.org/10.1039/d2fo02846h

TY - JOUR

T1 - Health associations of liver enzymes and inflammatory scores with urinary citrus flavonoid metabolites

AU - Bullón-Vela, Vanessa

AU - Xu, Yifan

AU - Razquin, Cristina

AU - Abete, Itziar

AU - Zulet, Maria Angeles

AU - Martínez-González, Miguel A

AU - Buil-Corsiales, Pilar

AU - Vitelli-Storelli, Facundo

AU - Martín Sánchez, Vicente

AU - Vazquez-Ruíz, Zenaida

AU - Sayón-Orea, Carmen

AU - Domínguez-Fernández, Maite

AU - Cid, Concepción

AU - Estruch, Ramon

AU - Lamuela-Raventós, Rosa María

AU - Fitó, Montserrat

AU - Blanchart, Gemma

AU - Babio, Nancy

AU - Salas-Salvadó, Jordi

AU - Tinahones, Francisco J

AU - Tur, Josep A

AU - Romaguera, Dora

AU - Konieczna, Jadwiga

AU - Pintó, Xavier

AU - Daimiel, Lidia

AU - Rodriguez-Mateos, Ana

AU - Martínez, José Alfredo

PY - 2022/12/23

Y1 - 2022/12/23

N2 - Background: Dietary flavonoid intake is associated with a reduced risk of some cardiometabolic disorders, attributed in part to their claimed anti-inflammatory activity. Our aim was to investigate the potential association between specific urine flavonoid metabolites, liver enzymes, and inflammatory status in individuals with metabolic syndrome (MetS). Methods: In this cross-sectional study, clinical and dietary data from 267 participants, aged 55 to 75 years, participating in the PREDIMED Plus study (PREvención con DIeta MEDiterránea) were analyzed. At the baseline, spot urine samples were collected and seven urinary flavonoid metabolites were quantified using ultra-performance liquid chromatography coupled to triple quadrupole mass spectrometry (UPLC-Q-q-Q MS). Liver enzymes, inflammatory scores, and urinary flavonoid concentrations were inverse normally transformed. Results: Adjusted linear regression models showed an inverse association between urinary citrus flavanone concentrations and gamma-glutamyl transferase (GGT) (all p-values <0.05). Naringenin 7'-GlcUA was significantly associated with a lower aggregate index of systemic inflammation (AISI) (Bper 1SD = -0.14; 95% CI: -0.27 to -0.02; p-value = 0.025) and systemic inflammation index (SII) (Bper 1SD = -0.14; 95% CI: -0.27 to -0.02; p-value = 0.028). To investigate the relationship between flavanone subclasses and GGT levels, we fitted a score of citrus-flavanones, and subjects were stratified into quartiles. The highest values of the citrus-flavanone score (per 1-SD increase) were associated with lower GGT levels (Bper 1SD = -0.41; 95% CI: -0.74 to -0.07), exhibiting a linear trend across quartiles (p-trend = 0.015). Conclusion: This cross-sectional study showed that higher urinary excretion of citrus-flavanone metabolites was associated with lower GGT levels in subjects diagnosed with MetS and obesity.

AB - Background: Dietary flavonoid intake is associated with a reduced risk of some cardiometabolic disorders, attributed in part to their claimed anti-inflammatory activity. Our aim was to investigate the potential association between specific urine flavonoid metabolites, liver enzymes, and inflammatory status in individuals with metabolic syndrome (MetS). Methods: In this cross-sectional study, clinical and dietary data from 267 participants, aged 55 to 75 years, participating in the PREDIMED Plus study (PREvención con DIeta MEDiterránea) were analyzed. At the baseline, spot urine samples were collected and seven urinary flavonoid metabolites were quantified using ultra-performance liquid chromatography coupled to triple quadrupole mass spectrometry (UPLC-Q-q-Q MS). Liver enzymes, inflammatory scores, and urinary flavonoid concentrations were inverse normally transformed. Results: Adjusted linear regression models showed an inverse association between urinary citrus flavanone concentrations and gamma-glutamyl transferase (GGT) (all p-values <0.05). Naringenin 7'-GlcUA was significantly associated with a lower aggregate index of systemic inflammation (AISI) (Bper 1SD = -0.14; 95% CI: -0.27 to -0.02; p-value = 0.025) and systemic inflammation index (SII) (Bper 1SD = -0.14; 95% CI: -0.27 to -0.02; p-value = 0.028). To investigate the relationship between flavanone subclasses and GGT levels, we fitted a score of citrus-flavanones, and subjects were stratified into quartiles. The highest values of the citrus-flavanone score (per 1-SD increase) were associated with lower GGT levels (Bper 1SD = -0.41; 95% CI: -0.74 to -0.07), exhibiting a linear trend across quartiles (p-trend = 0.015). Conclusion: This cross-sectional study showed that higher urinary excretion of citrus-flavanone metabolites was associated with lower GGT levels in subjects diagnosed with MetS and obesity.

U2 - 10.1039/d2fo02846h

DO - 10.1039/d2fo02846h

M3 - Article

C2 - 36562455

SN - 2042-6496

JO - Food & Function

JF - Food & Function

ER -

Health associations of liver enzymes and inflammatory scores with urinary citrus flavonoid metabolites

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