Health-related quality of life overview after different curative treatment options in muscle-invasive bladder cancer: an umbrella review

TY - JOUR

T1 - Health-related quality of life overview after different curative treatment options in muscle-invasive bladder cancer

T2 - an umbrella review

AU - Rammant, Elke

AU - Van Wilder, Lisa

AU - Van Hemelrijck, Mieke

AU - Pauwels, Nele S.

AU - Decaestecker, Karel

AU - Van Praet, Charles

AU - Bultijnck, Renée

AU - Ost, Piet

AU - Van Vaerenbergh, Thomas

AU - Verhaeghe, Sofie

AU - Van Hecke, Ann

AU - Fonteyne, Valérie

PY - 2020/11/1

Y1 - 2020/11/1

N2 - Purpose: This umbrella review aims to evaluate the quality, summarize and compare the conclusions of systematic reviews investigating the impact of curative treatment options on health-related quality of life (HRQoL) in muscle-invasive bladder cancer (MIBC). Methods: The Cochrane Library, MEDLINE, Embase and Web of Science were searched independently by two authors from inception until 06 January 2020. Systematic reviews and meta-analyses assessing the impact of any curative treatment option on HRQol in MIBC patients were eligible. Risk of bias was assessed using the AMSTAR 2 tool. Results: Thirty-two reviews were included. Robot-assisted RC with extracorporeal urinary diversion and open RC have similar HRQoL (n = 10). Evidence for pelvic organ-sparing RC was too limited (n = 2). Patients with a neobladder showed better overall and physical HRQoL outcomes, but worse urinary function in comparison with ileal conduit (n = 17). Bladder-preserving radiochemotherapy showed slightly better urinary and sexual but worse gastro-intestinal HRQoL outcomes in comparison with RC patients (n = 6). Quality of the reviews was low in more than 50% of the available reviews and most of the studies included in the reviews were nonrandomized studies. Conclusion: This umbrella review gives a comprehensive overview of the available evidence to date.

AB - Purpose: This umbrella review aims to evaluate the quality, summarize and compare the conclusions of systematic reviews investigating the impact of curative treatment options on health-related quality of life (HRQoL) in muscle-invasive bladder cancer (MIBC). Methods: The Cochrane Library, MEDLINE, Embase and Web of Science were searched independently by two authors from inception until 06 January 2020. Systematic reviews and meta-analyses assessing the impact of any curative treatment option on HRQol in MIBC patients were eligible. Risk of bias was assessed using the AMSTAR 2 tool. Results: Thirty-two reviews were included. Robot-assisted RC with extracorporeal urinary diversion and open RC have similar HRQoL (n = 10). Evidence for pelvic organ-sparing RC was too limited (n = 2). Patients with a neobladder showed better overall and physical HRQoL outcomes, but worse urinary function in comparison with ileal conduit (n = 17). Bladder-preserving radiochemotherapy showed slightly better urinary and sexual but worse gastro-intestinal HRQoL outcomes in comparison with RC patients (n = 6). Quality of the reviews was low in more than 50% of the available reviews and most of the studies included in the reviews were nonrandomized studies. Conclusion: This umbrella review gives a comprehensive overview of the available evidence to date.

UR - http://www.scopus.com/inward/record.url?scp=85086002984&partnerID=8YFLogxK

U2 - 10.1007/s11136-020-02544-z

DO - 10.1007/s11136-020-02544-z

M3 - Review article

AN - SCOPUS:85086002984

SN - 0962-9343

VL - 29

SP - 2887

EP - 2910

JO - Quality of Life Research

JF - Quality of Life Research

IS - 11

ER -