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Health-related quality of life overview after different curative treatment options in muscle-invasive bladder cancer: an umbrella review

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Elke Rammant, Lisa Van Wilder, Mieke Van Hemelrijck, Nele S. Pauwels, Karel Decaestecker, Charles Van Praet, Renée Bultijnck, Piet Ost, Thomas Van Vaerenbergh, Sofie Verhaeghe, Ann Van Hecke, Valérie Fonteyne

Original languageEnglish
Pages (from-to)2887-2910
Number of pages24
JournalQuality of Life Research
Issue number11
Accepted/In press1 Jan 2020
Published1 Nov 2020

King's Authors


Purpose: This umbrella review aims to evaluate the quality, summarize and compare the conclusions of systematic reviews investigating the impact of curative treatment options on health-related quality of life (HRQoL) in muscle-invasive bladder cancer (MIBC). Methods: The Cochrane Library, MEDLINE, Embase and Web of Science were searched independently by two authors from inception until 06 January 2020. Systematic reviews and meta-analyses assessing the impact of any curative treatment option on HRQol in MIBC patients were eligible. Risk of bias was assessed using the AMSTAR 2 tool. Results: Thirty-two reviews were included. Robot-assisted RC with extracorporeal urinary diversion and open RC have similar HRQoL (n = 10). Evidence for pelvic organ-sparing RC was too limited (n = 2). Patients with a neobladder showed better overall and physical HRQoL outcomes, but worse urinary function in comparison with ileal conduit (n = 17). Bladder-preserving radiochemotherapy showed slightly better urinary and sexual but worse gastro-intestinal HRQoL outcomes in comparison with RC patients (n = 6). Quality of the reviews was low in more than 50% of the available reviews and most of the studies included in the reviews were nonrandomized studies. Conclusion: This umbrella review gives a comprehensive overview of the available evidence to date.

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