Heart rate variability during sleep in healthy term newborns in the early postnatal period

TY - JOUR

T1 - Heart rate variability during sleep in healthy term newborns in the early postnatal period

AU - Doyle, O M

AU - Korotchikova, I

AU - Lightbody, G

AU - Marnane, W

AU - Kerins, D

AU - Boylan, G B

PY - 2009/8

Y1 - 2009/8

N2 - Normative time- and frequency-domain heart rate variability (HRV) measures were extracted during quiet sleep (QS) and active sleep (AS) periods in 30 healthy babies. All newborn infants studied were less than 12 h old and the sleep state was classified using multi-channel video EEG. Three bands were extracted from the heart rate (HR) spectrum: very low frequency (VLF), 0.01-0.04 Hz; low frequency (LF), 0.04-0.2 Hz, and high frequency (HF), >0.2 Hz. All metrics were averaged across all patients and per sleep state to produce a table of normative values. A noticeable peak corresponding to activity in the RSA band was found in 80% patients during QS and 0% of patients during AS, although some broadband activity was observed. The majority of HRV metrics showed a statistically significant separation between QS and AS. It can be concluded that (i) activity in the RSA band is present during QS in the healthy newborn, in the first 12 h of life, (ii) HRV measures are affected by sleep state and (iii) the averaged HRV metrics reported here could assist the interpretation of HRV data from newborns with neonatal illnesses.

AB - Normative time- and frequency-domain heart rate variability (HRV) measures were extracted during quiet sleep (QS) and active sleep (AS) periods in 30 healthy babies. All newborn infants studied were less than 12 h old and the sleep state was classified using multi-channel video EEG. Three bands were extracted from the heart rate (HR) spectrum: very low frequency (VLF), 0.01-0.04 Hz; low frequency (LF), 0.04-0.2 Hz, and high frequency (HF), >0.2 Hz. All metrics were averaged across all patients and per sleep state to produce a table of normative values. A noticeable peak corresponding to activity in the RSA band was found in 80% patients during QS and 0% of patients during AS, although some broadband activity was observed. The majority of HRV metrics showed a statistically significant separation between QS and AS. It can be concluded that (i) activity in the RSA band is present during QS in the healthy newborn, in the first 12 h of life, (ii) HRV measures are affected by sleep state and (iii) the averaged HRV metrics reported here could assist the interpretation of HRV data from newborns with neonatal illnesses.

KW - Heart Rate

KW - Sleep

KW - Humans

KW - Electroencephalography

KW - Infant, Newborn

KW - Time Factors

KW - Term Birth

U2 - 10.1088/0967-3334/30/8/009

DO - 10.1088/0967-3334/30/8/009

M3 - Article

C2 - 19590113

SN - 0967-3334

VL - 30

SP - 847

EP - 860

JO - Physiological Measurement

JF - Physiological Measurement

IS - 8

ER -