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Heat detection by the TRPM2 ion channel

Research output: Contribution to journalArticlepeer-review

Bruno Vilar, Chun Hsiang Tan, Peter McNaughton

Original languageEnglish
Pages (from-to)E5–E12
Number of pages7
JournalNATURE
Volume584
Published12 Aug 2020

Documents

  • TRPM2 MS as resubmitted 31 Jan 2020

    TRPM2_MS_as_resubmitted_31_Jan_2020.docx, 652 KB, application/vnd.openxmlformats-officedocument.wordprocessingml.document

    Uploaded date:28 May 2020

    Version:Accepted author manuscript

King's Authors

Abstract

The molecular mechanisms that underlie the distinct sensations of warmth and heat have remained unclear until recently. In 2016 we showed that the transient receptor potential (TRP) ion channel TRPM2 mediates the sensation of warmth in vivo in mice1, whereas in 2018 Vandewauw et al.2 found that three channels—TRPV1, TRPM3 and TRPA1—jointly mediate the sensation of painful heat. However, there was a discrepancy between the studies: we found that TRPM2 contributed to the thermal response of isolated somatosensory neurons1,3, whereas Vandewauw et al.2 proposed that TRPA1—and not TRPM2—was the only thermally activated ion channel in somatosensory neurons apart from TRPV1 and TRPM32. Here we show that both TRPM2 and TRPA1, in addition to the established thermosensory ion channels TRPV1 and TRPM3, drive responses of sensory neurons to increases of temperature.

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